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Multifunctional Core–Shell Structured Nanocarriers for Synchronous TumorDiagnosis and Treatment In Vivo
Dr. Yin‐Yin Chen1,2; Dr. Ping‐An Ma1; Dr. Dong‐Mei Yang1,2; Yuan Wu1,2; Dr. Yun‐Lu Dai1,2; Dr. Chun‐Xia Li1; Prof. Jun Lin1
2014-02
Source PublicationChemistry – An Asian Journal
ISSN1861-4728
Volume9Issue:2Pages:506-513
Abstract

Multifunctional, mesoporous, silica‐coated upconversion luminescent/magnetic NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2PEG (referred to as UCNPS; PEG=polyethylene glycol) nanocomposites were fabricated through a phase‐transfer‐assisted surfactant‐templating coating process, followed by hydrophilic polymer (PEG) functionalization to improve the stability and biocompatibility. The UCNP core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (MR) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. Proof‐of‐principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/MR dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers.

KeywordImaging Agents Luminescence Magnetic Properties Medicinal Chemistry Nanostructures
DOIhttps://doi.org/10.1002/asia.201301262
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000331088600018
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDr. Chun‐Xia Li; Prof. Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (P.R. China)
2.University of the Chinese Academy of Sciences, Beijing 100049 (P.R. China)
Recommended Citation
GB/T 7714
Dr. Yin‐Yin Chen,Dr. Ping‐An Ma,Dr. Dong‐Mei Yang,et al. Multifunctional Core–Shell Structured Nanocarriers for Synchronous TumorDiagnosis and Treatment In Vivo[J]. Chemistry – An Asian Journal,2014,9(2):506-513.
APA Dr. Yin‐Yin Chen.,Dr. Ping‐An Ma.,Dr. Dong‐Mei Yang.,Yuan Wu.,Dr. Yun‐Lu Dai.,...&Prof. Jun Lin.(2014).Multifunctional Core–Shell Structured Nanocarriers for Synchronous TumorDiagnosis and Treatment In Vivo.Chemistry – An Asian Journal,9(2),506-513.
MLA Dr. Yin‐Yin Chen,et al."Multifunctional Core–Shell Structured Nanocarriers for Synchronous TumorDiagnosis and Treatment In Vivo".Chemistry – An Asian Journal 9.2(2014):506-513.
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