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Mechanism of Drug Release from Compound Metformin/Glipizide Elementary Osmotic Pump Tablets
OUYANG De-fang1; MENG Jin1; KONG Cui-feng1,2; NIE Shu-fang1; PAN Wei-san1
2006-06-30
Source Publication中国药学英文版 = Journal of Chinese Pharmaceutical Sciences
ISSN1003-1057
Volume15Issue:2Pages:92-96
Abstract

In previous studies, compound metformin /glipizide elementary osmotic pump tablet was developed. Aim   To discover the mechanism of drug re lease from i.t Methods Three rate-limiting factors influencing drug re lease from dosage form (the semi-permeable membrane, tablet co re and delivery orifice) were investigated. Results The influx of water that passed the osmotic pump tablet was almost equal to the metformin release rate, while it was greatly less than the drug dissolution rate from tablet core. The size of orifice from 0.4mm to 0.8mm had no influence on drug release. The osmotic pressure of tablet co re was mainly caused by metformin. Conclusion From the developed model of osmotic pump system s, it can be seen that only the water influx through the membrane is a rate-limiting step, not tablet cored is solution rate and solution influx, and only when the core dissolution rate is equal to the solution influx, the zero order release is seen in the osmotic pump systems.

KeywordMetformin Glipizide Osmotic Pump Mechanism
Language英语
Fulltext Access
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorPAN Wei-san
Affiliation1.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
2.School of Traditional Chinese Medcine, Shenyang Pharmaceutical University, Shenyang 110016, China
Recommended Citation
GB/T 7714
OUYANG De-fang,MENG Jin,KONG Cui-feng,et al. Mechanism of Drug Release from Compound Metformin/Glipizide Elementary Osmotic Pump Tablets[J]. 中国药学英文版 = Journal of Chinese Pharmaceutical Sciences,2006,15(2):92-96.
APA OUYANG De-fang,MENG Jin,KONG Cui-feng,NIE Shu-fang,&PAN Wei-san.(2006).Mechanism of Drug Release from Compound Metformin/Glipizide Elementary Osmotic Pump Tablets.中国药学英文版 = Journal of Chinese Pharmaceutical Sciences,15(2),92-96.
MLA OUYANG De-fang,et al."Mechanism of Drug Release from Compound Metformin/Glipizide Elementary Osmotic Pump Tablets".中国药学英文版 = Journal of Chinese Pharmaceutical Sciences 15.2(2006):92-96.
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