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Compound Metformin Glipizide Bilayer Extended Release Tablets : Development and in Vitro Release
OUYANG De-fang; NIE Shu-fang; MENG Jin; YANG Xing-gang; SONG Zhi-quan; PAN Wei-san
2005-09-30
Source Publication中国药学英文版 = Journal of Chinese Pharmaceutical Sciences
ISSN1003-1057
Volume14Issue:3Pages:169-172
Abstract

Aim In this study , compound metformin glipizide bilayer extended release tablets were formulated with hydroxypropyl methylcellulose (HPMC)by wet granulation technique in order to tackle the problems associated with the multidrug therapy of non-insulin dependent diabetes mellitus .Methods   High-dose metformin is difficult to formulate into a tablet dosage form due to its poor compressibility and compactibility .In this study , the way to overcome the difficulty was to utilize stearic alcohol to prepare the tablet formulation .The influences of viscosity , amount of HPMC , and weight of fillers were investigated.The optimal formulation had acceptable physicochemical properties and released metformin and glipizide over 10 h .Results  The data of metformin obtained from in vitro release fittedHiguchi kinetics best , while the release of glipizide in vitro was found to follow zero kinetics. Conclusion  Compound metformin glipizide bilayer extended release tablets have been successfully developed .

KeywordMetformin Glipizide Extended Release Bilayer Tablet Stearic Alcohol
Language英语
Fulltext Access
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorPAN Wei-san
AffiliationDepartment of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016 , China
Recommended Citation
GB/T 7714
OUYANG De-fang,NIE Shu-fang,MENG Jin,et al. Compound Metformin Glipizide Bilayer Extended Release Tablets : Development and in Vitro Release[J]. 中国药学英文版 = Journal of Chinese Pharmaceutical Sciences,2005,14(3):169-172.
APA OUYANG De-fang,NIE Shu-fang,MENG Jin,YANG Xing-gang,SONG Zhi-quan,&PAN Wei-san.(2005).Compound Metformin Glipizide Bilayer Extended Release Tablets : Development and in Vitro Release.中国药学英文版 = Journal of Chinese Pharmaceutical Sciences,14(3),169-172.
MLA OUYANG De-fang,et al."Compound Metformin Glipizide Bilayer Extended Release Tablets : Development and in Vitro Release".中国药学英文版 = Journal of Chinese Pharmaceutical Sciences 14.3(2005):169-172.
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