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pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres
YunluDai1,2; Cuimiao Zhang1; Ziyong Cheng1; Ping’an Ma1; Chunxia Li1; Xiaojiao Kang1,2; Dongmei Yang1,2; Jun Lin1
Source PublicationBiomaterials

In this study, we design a controlled release system based on CaF2:Ce3þ/Tb3þ-poly(acrylic acid) (PAA) composite microspheres, which were fabricated by filling the pH-responsive PAA inside CaF2:Ce3þ/Tb3þ hollow spheres via photopolymerization route. The CaF2:Ce3þ/Tb3þ hollow spheres prepared by hydrothermal route possess mesoporous structure and show strong green fluorescence from Tb3þ under UV excitation. Doxorubicin hydrochloride (DOX), a widely used anti-cancer drug, was used as a model drug to evaluate the loading and controlled release behaviors of the composite microspheres due to the good biocompatibility of the samples using MTT assay. The composite carriers provide a strongly pH-dependent drug release behavior owing to the intrinsic property of PAA and its interactions with DOX. The endocytosis process of drug-loaded microspheres was observed using confocal laser scanning microscopy (CLSM) and the in vitro cytotoxic effect against SKOV3 ovarian cancer cells of the DOX-loaded carriers was investigated. In addition, the extent of drug release could be monitored by the altering of photoluminescence (PL) intensity of CaF2:Ce3þ/Tb3þ. Considering the good biocompatibility, high drug loading content and pH-dependent drug release of the materials, these hybrid luminescent microspheres have potential applications in drug controlled release and disease therapy.

KeywordDrug Carrier Poly(Acrylic Acid) Hollow Structure Doxorubicin Luminescence
Indexed BySCIE
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000300469800015
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Cited Times [WOS]:63   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZiyong Cheng; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
2.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
YunluDai,Cuimiao Zhang,Ziyong Cheng,et al. pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres[J]. Biomaterials,2012,33(8):2583-2592.
APA YunluDai,Cuimiao Zhang,Ziyong Cheng,Ping’an Ma,Chunxia Li,Xiaojiao Kang,Dongmei Yang,&Jun Lin.(2012).pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres.Biomaterials,33(8),2583-2592.
MLA YunluDai,et al."pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres".Biomaterials 33.8(2012):2583-2592.
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