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SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis
Qiang Chen1,2; Tenghui Chen1; Yixiang Xu1; Jingwei Zhu1; Yuan Jiang1; Yang Zhao1; Jianming Xu3; Chundong Yu1
2010
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume185Issue:9Pages:5444-5452
Abstract

Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial lipopolysaccharide-induced inflammation. However, its involvement in host defense against bacterial infection remains unclear. Herein we used SRC-3 knockout mice to assess the role of SRC-3 in antibacterial defense in E. coli-induced septic peritonitis. After E. coli bacteria were injected intraperitoneally, SRC-3 deficient mice exhibited excessive local and systemic inflammatory responses and more severe bacterial burdens, leading to a significantly higher mortality compared with wild-type mice. Peritoneal macrophages of SRC-3 deficient mice showed a decrease in bacterial phagocytosis in culture and an increase in apoptosis, which was consistent with the defective bacterial clearance observed in SRC-3-deficient mice. Accordingly, SRC-3 null macrophages expressed much lower levels of the scavenger receptor A, the antioxidant enzyme catalase, and anti-apoptotic gene Bcl-2. Collectively, our data demonstrate that SRC-3 is important in not only modulating the local and systemic inflammation but also intensifying bacterial clearance, which highlights a pivotal role of SRC-3 in the host defense system against bacterial infection.

DOIhttps://doi.org/10.4049/jimmunol.0903802
Indexed BySCIE
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000283248700057
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChundong Yu
Affiliation1.The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
2.The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
3.Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Recommended Citation
GB/T 7714
Qiang Chen,Tenghui Chen,Yixiang Xu,et al. SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis[J]. JOURNAL OF IMMUNOLOGY,2010,185(9):5444-5452.
APA Qiang Chen,Tenghui Chen,Yixiang Xu,Jingwei Zhu,Yuan Jiang,Yang Zhao,Jianming Xu,&Chundong Yu.(2010).SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis.JOURNAL OF IMMUNOLOGY,185(9),5444-5452.
MLA Qiang Chen,et al."SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis".JOURNAL OF IMMUNOLOGY 185.9(2010):5444-5452.
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