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PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin
Gang Li1,2; Yingchun Hu2; Yanying Huo2; Minli Liu2; Dan Freeman1; Jing Gao1; Xin Liu1; De-Chang Wu2; Hong Wu1

Tumor suppressor gene PTEN is highly mutated in a wide variety of human tumors. To identify unknown targets or signal transduction pathways that are regulated by PTEN, microarray analysis was performed to compare the gene expression profiles of Pten null mouse embryonic fibroblasts (MEFs) cell lines and their isogenic counterparts. Expression of a heparin binding growth factor, pleiotrophin (Ptn), was found to be up-regulated in Pten–/– MEFs as well as Pten null mammary tumors. Further experiments revealed that Ptn expression is regulated by the PTEN-PI3K-AKT pathway. Knocking down the expression of Ptn by small interfering RNA resulted in the reduction of Akt and GSK-3β phosphorylation and suppression of the growth and the tumorigenicity of Pten null MEFs. Our results suggest that PTN participates in tumorigenesis caused by PTEN loss and PTN may be a potential target for anticancer therapy, especially for those tumors with PTEN deficiencies.

Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000236822200004
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Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorHong Wu
Affiliation1.Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095-1735
2.Institute of Radiation Medicine, Beijing 100850, China
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GB/T 7714
Gang Li,Yingchun Hu,Yanying Huo,et al. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2006,281(16):10663-10668.
APA Gang Li,Yingchun Hu,Yanying Huo,Minli Liu,Dan Freeman,Jing Gao,Xin Liu,De-Chang Wu,&Hong Wu.(2006).PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin.JOURNAL OF BIOLOGICAL CHEMISTRY,281(16),10663-10668.
MLA Gang Li,et al."PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin".JOURNAL OF BIOLOGICAL CHEMISTRY 281.16(2006):10663-10668.
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