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Autophagy in ageing and ageing-associated diseases
He, Li-qiang1; Lu, Jia-hong1,2; Yue, Zhen-yu1
Source PublicationActa Pharmacologica Sinica

Autophagy is a cell self-digestion process via lysosomes that clears “cellular waste”, including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis. Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases. Lifespan of model organisms such as yeast, worms, flies, and mice can be extended through promoting autophagy, either by genetic manipulations such as over-expression of Sirtuin 1, or by administrations of rapamycin, resveratrol or spermidine. The evidence supports that autophagy may play an important role in delaying ageing or extending lifespan. In this review, we summarize the current knowledge about autophagy and its regulation, outline recent developments ie the genetic and pharmacological manipulations of autophagy that affects the lifespan, and discuss the role of autophagy in the ageing-related diseases.

KeywordAutophagy Neurodegenerative Diseases Sirtuin 1 P53 Rapamycin Resveratrol Spermidine Ageing Ageing-associated Diseases Cancer
Indexed BySCI
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000318733900005
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Cited Times [WOS]:57   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYue, Zhen-yu
Affiliation1.Departments of Neurology and Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
2.School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
Recommended Citation
GB/T 7714
He, Li-qiang,Lu, Jia-hong,Yue, Zhen-yu. Autophagy in ageing and ageing-associated diseases[J]. Acta Pharmacologica Sinica,2013,34(5):605-611.
APA He, Li-qiang,Lu, Jia-hong,&Yue, Zhen-yu.(2013).Autophagy in ageing and ageing-associated diseases.Acta Pharmacologica Sinica,34(5),605-611.
MLA He, Li-qiang,et al."Autophagy in ageing and ageing-associated diseases".Acta Pharmacologica Sinica 34.5(2013):605-611.
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