Phytol: A review of biomedical activities
Islam, Muhammad Torequl1,2; Ali, Eunus S.3,33; Uddin, Shaikh J.4; Shaw, Subrata5; Islam, Md Amirul4; Ahmed, Md Iqbal4; Shill, Manik Chandra6; Karmakar, Utpal Kumar4; Yarla, Nagendra Sastry7; Khan, Ishaq N.8; Billah, Md Morsaline9; Pieczynska, Magdalena D.10; Zengin, Gokhan11; Malainer, Clemens; Nicoletti, Ferdinando12; Gulei, Diana13; Berindan-Neagoe, Ioana13,14,15; Apostolov, Apostol16; Banach, Maciej17,18,19; Yeung, Andy W. K.20; El-Demerdash, Amr21,22; Xiao, Jianbo23; Dey, Prasanta24; Yele, Santosh25; Jozwik, Artur10; Strzalkowska, Nina10; Marchewka, Joanna10; Rengasamy, Kannan R. R.26; Horbanczuk, Jaroslaw10; Kamal, Mohammad Amjad28,29,30; Mubarak, Mohammad S.27; Mishra, Siddhartha K.31; Shilpi, Jamil A.4; Atanasov, Atanas G.10,32
AbstractPhytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NE-kappa B-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
KeywordPhytol Phytol metabolites Phytanic acid Plant-derived compounds Biological activities
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Indexed BySCIE
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000449242800009
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Cited Times [WOS]:66   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Ton Duc Thang Univ, Dept Management Sci & Technol Dev, Ho Chi Minh City 700000, Vietnam;
2.Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City 700000, Vietnam;
3.Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA 5042, Australia;
4.Khulna Univ, Sch Life Sci, Pharm Discipline, Khulna 9208, Bangladesh;
5.Broad Inst MIT & Harvard, 415 Main St, Cambridge, MA 02142 USA;
6.North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh;
7.Univ Hyderabad, Sch Life Sci, Dept Anim Biol, Hyderabad 500003, TN, India;
8.Khyber Med Univ, Inst Basic Med Sci, PK NeuroOncol Res Grp, Peshawar 25000, Pakistan;
9.Khulna Univ, Biotechnol & Genet Engn Discipline, Khulna 9208, Bangladesh;
10.Polish Acad Sci, Inst Genet & Anim Breeding, Jastrzebiec, Poland;
11.Selcuk Univ, Fac Sci, Dept Biol, Konya, Turkey;
12.Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy;
13.Iuliu Hatieganu Univ Med & Pharm, MEDFUTURE Res Ctr Adv Med, 23 Marinescu St, Cluj Napoca 400337, Romania;
14.Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Gen Biomed & Translat Med, 23 Marinescu St, Cluj Napoca 400337, Romania;
15.Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom & Expt Pathol, Republicii 34 St, Cluj Napoca 400015, Romania;
16.Agr Inst, BG-9700 Shumen, Bulgaria;
17.Med Univ Lodz, Chair Nephrol & Hypertens, Dept Hypertens, Lodz, Poland;
18.PMMHRI, Lodz, Poland;
19.Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland;
20.Univ Hong Kong, Fac Dent, Appl Oral Sci, Oral & Maxillofacial Radiol, Hong Kong, Hong Kong, Peoples R China;
21.MNHN, CNRS, UMR 7245, Mol Commun & Adaptat Microorganismes, Paris, France;
22.Mansoura Univ, Chem Dept, Fac Sci, Mansoura 35516, Egypt;
23.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China;
24.Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea;
25.SVKMs NMIMS, Sch Pharm & Technol Management, Shirpur, India;
26.REEF Environm Consultancy Serv, 2 Kamaraj St, Sp Nagar 605001, Puducherry, India;
27.Univ Jordan, Dept Chem, Amman 11942, Jordan;
28.King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia;
29.Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia;
30.Novel Global Community Educ Fdn, Hebersham, Australia;
31.Dr Harisingh Gour Cent Univ, Sch Biol Sci, Dept Zool, Sagar 470003, MP, India;
32.Univ Vienna, Fac Life Sci, Dept Pharrnacognosy, Althanstr 14, A-1090 Vienna, Austria;
33.Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, 320 E Super St, Chicago, IL 60611 USA
Recommended Citation
GB/T 7714
Islam, Muhammad Torequl,Ali, Eunus S.,Uddin, Shaikh J.,et al. Phytol: A review of biomedical activities[J]. FOOD AND CHEMICAL TOXICOLOGY,2018,121:82-94.
APA Islam, Muhammad Torequl.,Ali, Eunus S..,Uddin, Shaikh J..,Shaw, Subrata.,Islam, Md Amirul.,Ahmed, Md Iqbal.,Shill, Manik Chandra.,Karmakar, Utpal Kumar.,Yarla, Nagendra Sastry.,Khan, Ishaq N..,Billah, Md Morsaline.,Pieczynska, Magdalena D..,Zengin, Gokhan.,Malainer, Clemens.,Nicoletti, Ferdinando.,Gulei, Diana.,Berindan-Neagoe, Ioana.,Apostolov, Apostol.,Banach, Maciej.,...&Atanasov, Atanas G..(2018).Phytol: A review of biomedical activities.FOOD AND CHEMICAL TOXICOLOGY,121,82-94.
MLA Islam, Muhammad Torequl,et al."Phytol: A review of biomedical activities".FOOD AND CHEMICAL TOXICOLOGY 121(2018):82-94.
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