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Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC-MS
Fan, J. J.1; Li, C. H.2; Hu, Y. J.3; Chen, H.1; Yang, F. Q.1
2018-11
Source PublicationSOUTH AFRICAN JOURNAL OF BOTANY
ISSN0254-6299
Volume119Pages:325-334
Abstract

Aloe barbadensis, A. vera var. chinensis, A. ferox and A. arborescens are the most widely cultivated and used aloe species due to their potential and potent bioactivity. In this study, clot lysis and fibrin plate model were used to assess the in vitro thrombolytic and fibrinolysis activity of protein and phenolic extracts, as well as three pure compounds (aloin A, Aloin B and aloe emodin) from aloe. Meanwhile, the phenolic compounds in aloe were analyzed by high-performance liquid chromatography (HPLC) and LC-mass spectrometry (LC-MS). The in vitro thrombolytic and fibrinolytic activity assay results indicated that the protein and phenolic extracts of four aloe species had good dot lysis, fibrinolytic activity and enzyme activity, and aloin A and aloin B may be the main active ingredients. In addition, the chromatographic analysis shows obviously differences in components, such as aloenin A, isoaloeresin D and aloesin.

KeywordAloe Vera Fibrinolysis Thrombolytic Lc-ms Analysis Phenolic Compound Protein
DOI10.1016/j.sajb.2018.10.001
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPlant Sciences
WOS SubjectPlant Sciences
WOS IDWOS:000449688300040
PublisherELSEVIER SCIENCE BV
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, H.; Yang, F. Q.
Affiliation1.School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, PR China
2.Sunshine Lake Pharma Co. , LTD, Dongguan, Guangdong 523850, PR China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, PR China
Recommended Citation
GB/T 7714
Fan, J. J.,Li, C. H.,Hu, Y. J.,et al. Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC-MS[J]. SOUTH AFRICAN JOURNAL OF BOTANY,2018,119:325-334.
APA Fan, J. J.,Li, C. H.,Hu, Y. J.,Chen, H.,&Yang, F. Q..(2018).Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC-MS.SOUTH AFRICAN JOURNAL OF BOTANY,119,325-334.
MLA Fan, J. J.,et al."Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC-MS".SOUTH AFRICAN JOURNAL OF BOTANY 119(2018):325-334.
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