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Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies
Qing-E Zhang1; Fei Wang,2,3; Geng Qin4; Wei Zheng5; Chee H .Ng6; Gabor S. Ungvari7,8; Zhen Yuan,3; Songli Mei9; Gang Wang,1; Yu-Tao Xiang3
2018
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume14Issue:11Pages:1504-1512
Abstract

Depression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were rated as high quality. Compared to healthy controls, IBS patients had more frequent (OR=9.21, 95% CI: 4.56-18.57, P<0.001; I-2=76%) and more severe depressive symptoms (n=1,480, SMD=2.02, 95% CI: 1.56-2.48, P<0.001; I-2=94%). Subgroup analyses revealed that patients with all IBS subtypes had more severe depressive symptoms than controls. In addition, versions of the Hamilton Depression Rating Scale (HAM-D) and IBS diagnostic criteria were significantly associated with depressive symptom severity. Meta-regression analyses revealed that female gender, younger age and small sample size were significantly associated with more severe depressive symptoms. In conclusion, meta-analytic data showed that IBS patients had more frequent and severe depressive symptoms than healthy controls. Adequate screening and treatment for depression should be developed and implemented in this patient population.

KeywordIbs Depressive Symptoms Controlled Studies Meta-analysis
DOI10.7150/ijbs.25001
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000443994800012
PublisherIVYSPRING INT PUBL
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorGang Wang,; Yu-Tao Xiang
Affiliation1.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
2.Guangdong Mental Health Center, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangdong Province, China
3.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
4.Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China
5.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
6.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
7.University of Notre Dame Australia, Perth, Australia
8.Division of Psychiatry, University of Western Australia Medical School, Perth, Australia
9.School of Public Health, Jilin University, Jilin province, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Qing-E Zhang,Fei Wang,,Geng Qin,et al. Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2018,14(11):1504-1512.
APA Qing-E Zhang.,Fei Wang,.,Geng Qin.,Wei Zheng.,Chee H .Ng.,...&Yu-Tao Xiang.(2018).Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,14(11),1504-1512.
MLA Qing-E Zhang,et al."Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 14.11(2018):1504-1512.
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