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miRNA arm switching identifies novel tumour biomarkers
Chen, Liang1; Sun, Huiyan2; Wang, Changliang1; Yang, Yang1; Zhang, Menglei1; Wong, Garry1
Source PublicationEBIOMEDICINE
AbstractBackground: microRNAs have been reported to play critical roles in cancer and to have potential as diagnostic biomarkers. During miRNA biogenesis, one strand of the miRNA hairpin precursor is preferentially selected as a functionally mature miRNA, while the other strand is typically degraded. Arm switching occurs when the strand preference is changed. This preference can be different and can change dynamically depending upon the species, tissue types, or development stages. Due to recent advances in next-generation sequencing methods, arm switching has been observed in a variety of cancers.
KeywordmicroRNA Arm switching Pan-cancer Biomarker SVM Survival analysis
URLView the original
Indexed BySCI
WOS Research AreaGeneral & Internal Medicine ; Research & Experimental Medicine
WOS SubjectMedicine, General & Internal ; Medicine, Research & Experimental
WOS IDWOS:000454052500014
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Univ Macau, Fac Hlth Sci, Canc Ctr, Ctr Reprod Dev & Aging, Taipa, Macau, Peoples R China;
2.Jilin Univ, Coll Comp Sci & Technol, Key Lab Symbol Computat & Knowledge Engn, Minist Educ, Changchun 130012, Jilin, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chen, Liang,Sun, Huiyan,Wang, Changliang,et al. miRNA arm switching identifies novel tumour biomarkers[J]. EBIOMEDICINE,2018,38:37-46.
APA Chen, Liang,Sun, Huiyan,Wang, Changliang,Yang, Yang,Zhang, Menglei,&Wong, Garry.(2018).miRNA arm switching identifies novel tumour biomarkers.EBIOMEDICINE,38,37-46.
MLA Chen, Liang,et al."miRNA arm switching identifies novel tumour biomarkers".EBIOMEDICINE 38(2018):37-46.
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