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Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
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Sodium tanshinone IIA sulfonate  Salvia miltiorrhiza  Hemorrhagic stroke  Atorvastatin  ROCK  
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 128,Page: 389-398
Authors:  Huang, Bin;  Zhou, Zhong-Yan;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
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Tanshinone I  Vascular integrity  Endothelial cell adhesion  Hemorrhagic stroke  Zebrafish  HUVECs  
Ferulic acid relaxed rat aortic, small mesenteric and coronary arteries by blocking voltage-gated calcium channel and calcium desensitization via dephosphorylation of ERK1/2 and MYPT1 Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 815,Page: 26-32
Authors:  Zhou, Zhong-Yan;  Xu, Jia-Qi;  Zhao, Wai-Rong;  Chen, Xin-Lin;  Jin, Yu;  Tang, Nuo;  Tang, Jing-Yi
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Ferulic acid  Vasorelaxation  Calcium sensitization  Calcium channel  Endothelium  
Spatholobi Caulis extracts promote angiogenesis in HUVECs in vitro and in zebrafish embryos in vivo via up-regulation of VEGFRs Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2017,Volume: 200,Page: 74-83
Authors:  Zhou, Zhong-Yan;  Huan, Li-Yun;  Zhao, Wai-Rong;  Tang, Nuo;  Jin, Yu;  Tang, Jing-Yi
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Spatholobi Caulis  Flavonoids  Pro-angiogenesis  Zebrafish  HUVECs