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Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
Favorite | View/Download:36/0 | TC[WOS]:5 TC[Scopus]:8 | Submit date:2018/10/30
Sodium Tanshinone Iia Sulfonate  Salvia Miltiorrhiza  Hemorrhagic Stroke  Atorvastatin  Rock  
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 128,Page: 389-398
Authors:  Huang, Bin;  Zhou, Zhong-Yan;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
Favorite | View/Download:41/0 | TC[WOS]:2 TC[Scopus]:4 | Submit date:2018/10/30
Tanshinone i  Vascular Integrity  Endothelial Cell Adhesion  Hemorrhagic Stroke  Zebrafish  Huvecs  
Ferulic acid relaxed rat aortic, small mesenteric and coronary arteries by blocking voltage-gated calcium channel and calcium desensitization via dephosphorylation of ERK1/2 and MYPT1 Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 815,Page: 26-32
Authors:  Zhou, Zhong-Yan;  Xu, Jia-Qi;  Zhao, Wai-Rong;  Chen, Xin-Lin;  Jin, Yu;  Tang, Nuo;  Tang, Jing-Yi
Favorite | View/Download:16/0 | TC[WOS]:7 TC[Scopus]:9 | Submit date:2018/10/30
Ferulic acid  Vasorelaxation  Calcium sensitization  Calcium channel  Endothelium  
Spatholobi Caulis extracts promote angiogenesis in HUVECs in vitro and in zebrafish embryos in vivo via up-regulation of VEGFRs Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2017,Volume: 200,Page: 74-83
Authors:  Zhou, Zhong-Yan;  Huan, Li-Yun;  Zhao, Wai-Rong;  Tang, Nuo;  Jin, Yu;  Tang, Jing-Yi
Favorite | View/Download:16/0 | TC[WOS]:11 TC[Scopus]:16 | Submit date:2018/10/30
Spatholobi Caulis  Flavonoids  Pro-angiogenesis  Zebrafish  HUVECs  
Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis Journal article
Journal of Ethnopharmacology, 2016,Volume: 181,Page: 50
Authors:  Bin-Rui Yang;  Kwok-Kuen Cheung;  Xin Zhou;  Rui-Fang Xie;  Pei-Pei Cheng;  Shen Wu;  Zhong-Yan Zhou;  Jing Yi Tang;  Pui Man Hoi;  You-Hua Wang;  Simon Ming-Yuen Lee
Favorite | View/Download:9/0 | TC[WOS]:37 TC[Scopus]:41 | Submit date:2018/10/30
Angiogenesis  Apoptosis  Myocardial Infarction  Panax Notoginseng Flower  Saponin  
Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models Journal article
Free Radical Biology and Medicine, 2015,Volume: 89,Page: 1057-1066
Authors:  Cheong-Meng Chong;  Dan Ma;  Chao Zhao;  Robin J.M. Franklin;  Zhong-Yan Zhou;  Nana Ai;  Chuwen Li;  Huidong Yu;  Tingjun Hou;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:20/0 | TC[WOS]:11 TC[Scopus]:14 | Submit date:2018/11/06
Mpp++++  Neurodegeneration  Rat Organotypiccerebellarcultures  Zebrafish  
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3 β pathways Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2015,Volume: 170,Page: 8-15
Authors:  Lun Qing Zhang;  Fei Sa;  Cheong Meng Chong;  Ying Wang;  Zhong Yan Zhou;  Raymond Chuen Chung Chang;  Shun Wan Chan;  Pui Man Hoi;  Simon Ming Yuen Lee
Favorite | View/Download:6/0 | TC[WOS]:23 TC[Scopus]:28 | Submit date:2020/04/15
6-hydroxydopamine (6-ohda)  Oxidative Stress  Parkinson׳s Disease  Schisantherin a