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Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β Journal article
Neuroscience Letters, 2018,Volume: 687,Page: 207-215
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
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3xTg-AD mice  BV-2 cells  GSK-3β  Neuroinflammation  SLOH  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
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cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Identification of a Wells-Dawson polyoxometalatebased AP-2γ inhibitor with pro-apoptotic activity Journal article
Biochemical Journal, 2018,Volume: 475,Issue: 11,Page: 1965-1977
Authors:  Hu J.;  Tan S.K.;  Lim M.G.L.;  Chang S.H.;  Cui G.;  Liu S.;  Narasimhan K.;  New S.Y.;  Wang X.;  Chen C.;  Chakravarty H.;  Kolatkar P.R.;  Tam K.Y.;  Lu Q.;  Su X.;  Jauch R.;  Cheung E.
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Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
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Anti-proliferation  Binding affinity  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 101-108
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
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Alzheimer's Disease  Glycogen Synthase Kinase-3β  Okadaic Acid  Slm  Tau Hyperphosphorylation  
Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 70-76
Authors:  Guo L.X.;  Liu J.H.;  Zheng X.X.;  Yin Z.Y.;  Kosaraju J.;  Tam K.Y.
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Apoptosis  Geniposide  Glucose-stimulated Insulin Secretion  Glucotoxicity  
Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease Journal article
ACS Chemical Neuroscience, 2017,Volume: 8,Issue: 3,Page: 676-685
Authors:  Wu X.;  Kosaraju J.;  Zhou W.;  Tam K.Y.
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3xtg-ad  Aggregation  Alzheimer’s Disease  Amyloid β  Neuroprotection  Sh-sy5y  Slm  
Association of vancomycin with lipid vesicles Journal article
ADMET and DMPK, 2017,Volume: 5,Issue: 3,Page: 182-191
Authors:  Hu X.;  Tam K.Y.
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Antibiotics  Binding  Liposome  Membrane  Phospholipids  
Quinazolinone azolyl ethanols: Potential lead antimicrobial agents with dual action modes targeting methicillin-resistant Staphylococcus aureus DNA Journal article
Future Medicinal Chemistry, 2016,Volume: 8,Issue: 16,Page: 1927-1940
Authors:  Peng X.-M.;  Peng L.-P.;  Li S.;  Avula S.R.;  Kannekanti V.K.;  Zhang S.-L.;  Tam K.Y.;  Zhou C.-H.
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Antibacterial  Antifungal  Dna Cleavage  Dna Intercalation  Imidazole  Quinazolinone  Triazole  
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 7,Page: 3562-3568
Authors:  Zhang S.-L.;  Hu X.;  Zhang W.;  Tam K.Y.
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