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Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions Journal article
Journal of Pharmaceutical Sciences, 2021,Volume: 110,Issue: 3,Page: 1160-1171
Authors:  Zhang,Xiaoting;  Rao,Qiuhong;  Qiu,Zhenwen;  Lin,Yisheng;  Zhang,Lei;  Hu,Qingzhong;  Chen,Tingting;  Ma,Zhimin;  Gao,Hanlu;  Luo,Dandong;  Zhao,Jiaqi;  Ouyang,Defang;  Zhang,Zhenyu Jason;  Li,Qingguo
Favorite | View/Download:0/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
Amorphous solid dispersion  Drug-excipient interaction  Particle size  Poorly water-soluble drug  Spray drying  
An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design Journal article
European Journal of Pharmaceutics and Biopharmaceutics, 2021,Volume: 158,Page: 336-346
Authors:  Gao,Hanlu;  Wang,Wei;  Dong,Jie;  Ye,Zhuyifan;  Ouyang,Defang
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Dissolution profile  Machine learning  molecular dynamics (MD) simulations  Pharmacokinetic modeling  Solid dispersion  
Simultaneous extraction, separation, isolation and identification of endogenous components from Etlingera elatior by pressurized matrix solid-phase dispersion using liquid chromatography–mass spectrometry Journal article
Journal of Chromatography A, 2020,Volume: 1611
Authors:  Ge,Liya;  Yong,Jean Wan Hong;  Tan,Swee Ngin;  Li,Shao Ping
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Etlingera elatior  LC–MS  NMR  Pressurized matrix solid-phase dispersion  Sample preparation  
Predicting physical stability of solid dispersions by machine learning techniques Journal article
Journal of Controlled Release, 2019,Volume: 311-312,Page: 16-25
Authors:  Han,Run;  Xiong,Hui;  Ye,Zhuyifan;  Yang,Yilong;  Huang,Tianhe;  Jing,Qiufang;  Lu,Jiahong;  Pan,Hao;  Ren,Fuzheng;  Ouyang,Defang
Favorite | View/Download:0/0 | TC[WOS]:18 TC[Scopus]:21 | Submit date:2021/03/02
Machine learning  Molecular modeling  Physical stability  Solid dispersion  
Insight into the Dissolution Molecular Mechanism of Ternary Solid Dispersions by Combined Experiments and Molecular Simulations Journal article
AAPS PHARMSCITECH, 2019,Volume: 20,Issue: 7
Authors:  Run Han;  Tianhe Huang;  Xinyang Liu;  Xinyang Liu;  Haifeng Li;  Jiahong Lu;  Yuanhui Ji;  Huimin Sun;  Defang Ouyang
Favorite | View/Download:18/0 | TC[WOS]:4 TC[Scopus]:3 | Submit date:2020/03/25
Solid Dispersion  Dissolution Effect  Molecular Modeling  Ternary System  
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 Journal article
MOLECULES, 2018,Volume: 23,Issue: 7
Authors:  Zhang, Jinglu;  Han, Run;  Chen, Weijie;  Zhang, Weixiang;  Li, Ying;  Ji, Yuanhui;  Chen, Lijiang;  Pan, Hao;  Yang, Xinggang;  Pan, Weisan;  Ouyang, Defang
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Solid Dispersion  Big Data  Literature  Patent  Scientific Knowledge Mapping  Citespace  
Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations Journal article
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 13,Issue: 3,Page: 248-254
Authors:  Chan, TengIan;  Ouyang, Defang
Favorite | View/Download:28/0 | TC[WOS]:11 TC[Scopus]:13 | Submit date:2018/10/30
Solid Dispersion  Molecular Modeling  Dissolution Process  Ibuprofen  
Investigation of molecular dissolution mechanism of ketoprofen binary and ternary solid dispersions by molecular dynamics simulations Journal article
Molecular Simulation, 2017,Volume: 43,Issue: 13-16,Page: 1074-1080
Authors:  Chen W.;  Ouyang D.
Favorite | View/Download:9/0 | TC[WOS]:6 TC[Scopus]:8 | Submit date:2019/01/15
Dissolution Mechanism  Ketoprofen  Molecular Dynamics  Solid Dispersion  Surfactant  
Preparation and characterization of pelletized solid dispersion of resveratrol with mesoporous silica microparticles to improve dissolution by fluid-bed coating techniques Journal article
Asian Journal of Pharmaceutical Sciences, 2016,Volume: 11,Issue: 4,Page: 528-535
Authors:  Jian Li;  Xiaoqing Miao;  Tongkai Chen;  Defang Ouyang;  Ying Zheng
Favorite | View/Download:16/0 | TC[WOS]:9 TC[Scopus]:13 | Submit date:2018/12/28
Amorphous  Fluid Bed  Mesoporous Silica Microparticles (Msm)  Resveratrol (Res)  Solid Dispersion  
Application of solid dispersion combined with carriers for in vitro release of multi-components from Danshen extract Journal article
Chinese Traditional and Herbal Drugs, 2011,Volume: 42,Issue: 1,Page: 50
Authors:  Xiong X.-L.;  Zheng Y.;  Wang Y.-T.
Favorite | View/Download:8/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/10/31
Characterization  Combined carriers  In vitro release  Salviae Miltiorrhizae Radix et Rhizoma (Danshen)  Solid dispersion