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Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
ACS Chemical Biology, 2017,Volume: 12,Issue: 1,Page: 174
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.;  Pasunooti K.K.;  Li R.-J.;  Shim J.S.;  Liu J.O.
Favorite | View/Download:10/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2018/10/30
Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Cho Y.S.;  Yen C.-N.;  Shim J.S.;  Kang D.H.;  Kang S.W.;  Liu J.O.;  Kwon H.J.
Favorite | View/Download:9/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2019/01/15
Revisiting Non-Cancer Drugs for Cancer Therapy Journal article
Current Topics in Medicinal Chemistry, 2016,Volume: 16,Issue: 19,Page: 2144-2155
Authors:  Yang E.J.;  Wu C.;  Liu Y.;  Lv J.;  Shim J.S.
Favorite | View/Download:10/0 | TC[WOS]:5 TC[Scopus]:0 | Submit date:2019/01/15
Cancer  Disulfiram  Doxycycline  Drug Repositioning  Existing Drugs  Mebendazole  Pyrvinium Pamoate  Triclosan  
Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Clinical Cancer Research, 2016,Volume: 22,Issue: 11,Page: 2709-2720
Authors:  Shim J.S.;  Li R.-J.;  Bumpus N.N.;  Head S.A.;  Pasunooti K.K.;  Yang E.J.;  Lv J.;  Shi W.;  Liu J.O.
Favorite | View/Download:11/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2019/01/15
The small molecule R-(-)-β-O-methylsynephrine binds to nucleoporin 153 kDa and inhibits angiogenesis Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 9,Page: 1088-1099
Authors:  Kim N.H.;  Pham N.B.;  Quinn R.J.;  Shim J.S.;  Cho H.;  Cho S.M.;  Park S.W.;  Kim J.H.;  Seok S.H.;  Oh J.-W.;  Kwon H.J.
Favorite | View/Download:8/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2019/01/15
Angiogenesis  Natural Product  Nup153  Small Molecule  Target Identification  
Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism Journal article
Cancer Letters, 2015,Volume: 362,Issue: 1,Page: 106-115
Authors:  Shim J.S.;  Li R.-J.;  Lv J.;  Head S.A.;  Yang E.J.;  Liu J.O.
Favorite | View/Download:10/0 | TC[WOS]:10 TC[Scopus]:0 | Submit date:2019/01/15
Angiogenesis  Cholesterol Trafficking  Selective Estrogen Receptor Modulator  Tamoxifen  
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Proceedings of the National Academy of Sciences of the United States of America, 2015,Volume: 112,Issue: 52,Page: E7276
Authors:  Head S.A.;  Shi W.;  Zhao L.;  Gorshkov K.;  Pasunooti K.;  Chen Y.;  Deng Z.;  Li R.-J.;  Shim J.S.;  Tan W.;  Hartung T.;  Zhang J.;  Zhao Y.;  Colombini M.;  Liu J.O.
Favorite | View/Download:9/0 | TC[WOS]:47 TC[Scopus]:0 | Submit date:2018/10/30
Angiogenesis  Itraconazole  Metabolism  Mitochondria  VDAC1  
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass Journal article
eLife, 2015,Volume: 4,Issue: 2015-07-01
Authors:  Wang G.;  Rajpurohit S.K.;  Delaspre F.;  Walker S.L.;  White D.T.;  Ceasrine A.;  Kuruvilla R.;  Li R.-J.;  Shim J.S.;  Liu J.O.;  Parsons M.J.;  Mumm J.S.
Favorite | View/Download:11/0 | TC[WOS]:31 TC[Scopus]:0 | Submit date:2018/10/30
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
British Journal of Pharmacology, 2014,Volume: 171,Issue: 19,Page: 4478-4489
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.;  Das M.;  Liu J.O.
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Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model Journal article
Biochemical and Biophysical Research Communications, 2014,Volume: 450,Issue: 1,Page: 561-567
Authors:  Park H.;  Shim J.S.;  Kim B.S.;  Jung H.J.;  Huh T.-L.;  Kwon H.J.
Favorite | View/Download:14/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2019/01/15
Adipocyte-derived Leucine Aminopeptidase (A-lap)  Angiogenesis  Drug Screening  Purpurin