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A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Xinhua Zhou;  Anqi Wang;  Liang Wang;  Jianhua Yin;  Li Wang;  Lijun Di;  Maggie Pui-Man Hoi;  Luchen Shan;  Xu Wu;  Yuqiang Wang
Favorite | View/Download:12/0 | TC[WOS]:2 TC[Scopus]:3 | Submit date:2020/05/21
Danshensu  Tetramethylpyrazine  Breast Cancer  Resistance  Glycolysis  P-glycoprotein  
A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells Journal article
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019,Volume: 120,Issue: 4,Page: 5913-5922
Authors:  Ying Zhang;  Hongkuan Deng;  Hefeng Zhou;  Yucong Lu;  Luchen Shan;  Simon Ming‐Yuen Lee;  Guozhen Cui
Favorite | View/Download:248/0 | TC[WOS]:6 TC[Scopus]:6 | Submit date:2020/01/16
Antitumor  Biotin-conjugated Adtm Analog (Baa)  Cardioprotection  Cardiotoxicity  Doxorubicin (Dox)  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite | View/Download:28/0 | TC[WOS]:6 TC[Scopus]:8 | Submit date:2018/10/30
Alzheimer's disease  tetramethylpyrazine derivative  NMDA receptor  neuroprotection  oxidative stress  GSK3 beta  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
Favorite | View/Download:26/0 | TC[WOS]:16 TC[Scopus]:14 | Submit date:2018/10/30
Cardioprotection  Anti-oxidative Stress  Anti-apoptosis  Autophagy Regulation  Zebrafish Cardiotoxicity  H9c2 Cardiomyocytes  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
American Journal of Chinese Medicine, 2016,Volume: 44,Issue: 7,Page: 1349-1361
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang;  Simon Ming-Yuen Lee
Favorite | View/Download:10/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells Journal article
Journal of Cellular Biochemistry, 2016,Volume: 117,Issue: 1,Page: 94-105
Authors:  Liang Wang;  Xiaojing Zhang;  Judy Yuet‐Wa Chan;  Luchen Shan;  Guozhen Cui;  Qingbin Cui;  Yingfei Wang;  Jingjing Li;  Huanxian Chen;  Qingwen Zhang;  Pei Yu;  Yifan Han;  Yuqiang Wang;  Simon Ming‐Yuen Lee
Favorite | View/Download:15/0 | TC[WOS]:17 TC[Scopus]:20 | Submit date:2018/11/06
Breast Cancer  Cardiotoxicity  Doxorubicin  Mitochondrial Biogenesis  
Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents Journal article
RSC Advances, 2015,Volume: 5,Issue: 91,Page: 74605-74610
Authors:  Guozhen Cui;  Luchen Shan;  Ivan Keung Chu;  Guohui Li;  George Pak Heng Leung;  Yuqiang Wang;  Yiu Wa KWAN;  Shun Wan CHAN;  Maggie Pui Man Hoi;  Simon Ming Yuen Lee
Favorite | View/Download:11/0 | TC[WOS]:8 TC[Scopus]:9 | Submit date:2018/11/06
Synthesis and relationship of stability and biological activity of new DSS and TMP conjugates Journal article
MedChemComm, 2015,Volume: 6,Issue: 4,Page: 586-591
Authors:  Yewei Sun;  Zicheng Tan;  Zhibin Liang;  Liang Wang;  Luchen Shan;  Pei Yu;  Simon MingYuen Lee;  Yuqiang Wang
Favorite | View/Download:13/0 | TC[WOS]:3 TC[Scopus]:4 | Submit date:2018/11/06
Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy Journal article
Scientific Reports, 2015,Volume: 5
Authors:  Guozhen Cui;  Luchen Shan;  Lin Guo;  Ivan Keung Chu;  Guohui Li;  Quan Quan;  Yun Zhao;  Cheong Meng Chong;  Zaijun Zhang;  Pei Yu;  Maggie Pui Man Hoi;  Yewei Sun;  Yuqiang Wang;  Simon MingYuen Lee
Favorite | View/Download:13/0 | TC[WOS]:0 TC[Scopus]:14 | Submit date:2018/10/30