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Anti-tumor effects of a ‘human & mouse cross-reactive’ anti-ADAM17 antibody in a pancreatic cancer model in vivo Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 62-69
Authors:  Ye J.;  Yuen S.M.;  Murphy G.;  Xie R.;  Kwok H.F.
Favorite | View/Download:14/0 | TC[WOS]:6 TC[Scopus]:7 | Submit date:2018/12/19
Adam17  Inhibitory Antibody  Pancreatic Ductal Adenocarcinoma (Pdac)  Targeted Therapy  Tumorigenesis  
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview Journal article
British Journal of Pharmacology, 2017,Volume: 174,Page: S1-S16
Authors:  Alexander S.P.H.;  Kelly E.;  Marrion N.V.;  Peters J.A.;  Faccenda E.;  Harding S.D.;  Pawson A.J.;  Sharman J.L.;  Southan C.;  Buneman O.P.;  Cidlowski J.A.;  Christopoulos A.;  Davenport A.P.;  Fabbro D.;  Spedding M.;  Striessnig J.;  Davies J.A.;  Abbracchio M.-P.;  Aldrich R.;  Al-Hosaini K.;  Arumugam T.V.;  Attali B.;  Back M.;  Barnes N.M.;  Bathgate R.;  Beart P.M.;  Becirovic E.;  Bettler B.;  Biel M.;  Birdsall N.J.;  Blaho V.;  Boison D.;  Brauner-osborne H.;  Broer S.;  Bryant C.;  Burnstock G.;  Calo G.;  Catterall W.A.;  Ceruti S.;  Chan S.L.;  Chandy K.G.;  Chazot P.;  Chiang N.;  Chun J.J.;  Chung J.-J.;  Clapham D.E.;  Clapp L.;  Connor M.A.;  Cox H.M.;  Davies P.;  Dawson P.A.;  Decaen P.;  Dent G.;  Doherty P.;  Douglas S.D.;  Dubocovich M.L.;  Fong T.M.;  Fowler C.J.;  Frantz A.;  Fuller P.;  Fumagalli M.;  Futerman A.H.;  Gainetdinov R.R.;  Gershengorn M.A.;  Goldin A.;  Goldstein S.A.N.;  Goudet C.;  Gregory K.;  Grissmer S.;  Gundlach A.L.;  Hagenbuch B.;  Hamann J.;  Hammond J.R.;  Hancox J.C.;  Hanson J.;  Hanukoglu I.;  Hay D.L.;  Hobbs A.J.;  Hollenberg A.N.;  Holliday N.D.;  Hoyer D.;  Ijzerman A.P.;  Inui K.I.;  Irving A.J.;  Ishii S.;  Jacobson K.A.;  Jan L.Y.;  Jarvis M.F.;  Jensen R.;  Jockers R.;  Kaczmarek L.K.;  Kanai Y.;  Karnik S.;  Kellenberger S.;  Kemp S.;  Kennedy C.;  Kerr I.D.;  Kihara Y.;  Kukkonen J.;  Larhammar D.;  Leach K.;  Lecca D.;  Leeman S.;  Leprince J.;  Lolait S.J.;  Macewan D.;  Maguire J.J.;  Marshall F.;  Mazella J.;  Mcardle C.A.;  Michel M.C.;  Miller L.J.;  Mitolo V.;  Mizuno H.;  Monk P.N.;  Mouillac B.;  Murphy P.M.;  Nahon J.-L.;  Nerbonne J.;  Nichols C.G.;  Norel X.;  Offermanns S.;  Palmer L.G.;  Panaro M.A.;  Papapetropoulos A.;  Perez-reyes E.;  Pertwee R.G.;  Pintor S.;  Pisegna J.R.;  Plant L.D.;  Poyner D.R.;  Prossnitz E.R.;  Pyne S.;  Ramachandran R.;  Ren D.;  Rondard P.;  Ruzza C.;  Sackin H.;  Sanger G.;  Sanguinetti M.C.;  Schild L.;  Schioth H.;  Schulte G.;  Schulz S.;  Segaloff D.L.;  Serhan C.N.;  Singh K.D.;  Slesinger P.A.;  Snutch T.P.;  Sobey C.G.;  Stewart G.;  Stoddart L.A.;  Summers R.J.;  Szabo C.;  Thwaites D.;  Toll L.;  Trimmer J.S.;  Tucker S.;  Vaudry H.;  Verri T.;  Vilargada J.-P.;  Waldman S.A.;  Ward D.T.;  Waxman S.G.;  Wei A.D.;  Willars G.B.;  Wong S.S.;  Woodruff T.M.;  Wulff H.;  Ye R.D.;  Yung Y.;  Zajac J.-M.
Favorite | View/Download:27/0 | TC[WOS]:208 TC[Scopus]:170 | Submit date:2018/11/07
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo Journal article
Oncotarget, 2016,Volume: 7,Issue: 13,Page: 16773-16792
Authors:  Botkjaer K.A.;  Kwok H.F.;  Terp M.G.;  Karatt-Vellatt A.;  Santamaria S.;  McCafferty J.;  Andreasen P.A.;  Itoh Y.;  Ditzel H.J.;  Murphy G.
Favorite | View/Download:9/0 | TC[WOS]:21 TC[Scopus]:25 | Submit date:2018/12/19
Antibody  In Vivo targetIng  Metastasis  Mt1-mmp  Non-catalytic Sites  
Targeting the sheddase activity of Adam17 by an Anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 7,Page: 702-714
Authors:  Huang Y.;  Benaich N.;  Tape C.;  Kwok H.F.;  Murphy G.
Favorite | View/Download:9/0 | TC[WOS]:21 TC[Scopus]:28 | Submit date:2018/12/19
Adam17  Cell Proliferation And Motility  Her Receptor And ligAnds  Inhibitory Antibody  
Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy Journal article
Protein Engineering, Design and Selection, 2014,Volume: 27,Issue: 6,Page: 179-190
Authors:  Kwok H.F.;  Botkjaer K.A.;  Tape C.J.;  Huang Y.;  McCafferty J.;  Murphy G.
Favorite | View/Download:9/0 | TC[WOS]:20 TC[Scopus]:22 | Submit date:2018/12/19
Anti-tace Antibody  Exosite  Immunoreactivity  Phage-display Randomization Libraries  Sub-nanomolar Affinity  
The phototoxicity of some 1,3-butadienes and related thiophenes against larvae of the mosquito Aedes aegypti and of the fruit fly Drosophila melanogaster Journal article
International Journal of Tropical Insect Science, 1983,Volume: 4,Issue: 4,Page: 377-381
Authors:  Jacques Kagan;  Jean-Pierre Beny;  Ging Chan;  Som N. Dhawan;  Jeffery A. Jaworski;  Edgard D. Kagan;  Paul D. Kassner;  Margaret Murphy;  Judy A. Rogers
Favorite | View/Download:9/0 | TC[WOS]:21 TC[Scopus]:0 | Submit date:2019/01/07
Uva  Phototoxins  Photoantibiotic Compounds  Photolarvicides