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Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
ACS Chemical Biology, 2017,Volume: 12,Issue: 1,Page: 174
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.;  Pasunooti K.K.;  Li R.-J.;  Shim J.S.;  Liu J.O.
Favorite | View/Download:11/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2018/10/30
Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Cho Y.S.;  Yen C.-N.;  Shim J.S.;  Kang D.H.;  Kang S.W.;  Liu J.O.;  Kwon H.J.
Favorite | View/Download:9/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2019/01/15
Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Clinical Cancer Research, 2016,Volume: 22,Issue: 11,Page: 2709-2720
Authors:  Shim J.S.;  Li R.-J.;  Bumpus N.N.;  Head S.A.;  Pasunooti K.K.;  Yang E.J.;  Lv J.;  Shi W.;  Liu J.O.
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Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism Journal article
Cancer Letters, 2015,Volume: 362,Issue: 1,Page: 106-115
Authors:  Shim J.S.;  Li R.-J.;  Lv J.;  Head S.A.;  Yang E.J.;  Liu J.O.
Favorite | View/Download:10/0 | TC[WOS]:10 TC[Scopus]:0 | Submit date:2019/01/15
Angiogenesis  Cholesterol Trafficking  Selective Estrogen Receptor Modulator  Tamoxifen  
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Proceedings of the National Academy of Sciences of the United States of America, 2015,Volume: 112,Issue: 52,Page: E7276
Authors:  Head S.A.;  Shi W.;  Zhao L.;  Gorshkov K.;  Pasunooti K.;  Chen Y.;  Deng Z.;  Li R.-J.;  Shim J.S.;  Tan W.;  Hartung T.;  Zhang J.;  Zhao Y.;  Colombini M.;  Liu J.O.
Favorite | View/Download:11/0 | TC[WOS]:47 TC[Scopus]:0 | Submit date:2018/10/30
Angiogenesis  Itraconazole  Metabolism  Mitochondria  VDAC1  
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass Journal article
eLife, 2015,Volume: 4,Issue: 2015-07-01
Authors:  Wang G.;  Rajpurohit S.K.;  Delaspre F.;  Walker S.L.;  White D.T.;  Ceasrine A.;  Kuruvilla R.;  Li R.-J.;  Shim J.S.;  Liu J.O.;  Parsons M.J.;  Mumm J.S.
Favorite | View/Download:11/0 | TC[WOS]:31 TC[Scopus]:0 | Submit date:2018/10/30
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
British Journal of Pharmacology, 2014,Volume: 171,Issue: 19,Page: 4478-4489
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.;  Das M.;  Liu J.O.
Favorite | View/Download:11/0 | TC[WOS]:17 TC[Scopus]:0 | Submit date:2019/01/15
Personalized chemotherapy profiling using cancer cell lines from selectable mice Journal article
Clinical Cancer Research, 2013,Volume: 19,Issue: 5,Page: 1139-1146
Authors:  Kamiyama H.;  Rauenzahn S.;  Shim J.S.;  Karikari C.A.;  Feldmann G.;  Hua L.;  Kamiyama M.;  Schuler F.W.;  Lin M.-T.;  Beaty R.M.;  Karanam B.;  Liang H.;  Mullendore M.E.;  Mo G.;  Hidalgo M.;  Jaffee E.;  Hruban R.H.;  Jinnah H.A.;  Roden R.B.S.;  Jimeno A.;  Liu J.O.;  Maitra A.;  Eshleman J.R.
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Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir Journal article
Journal of the National Cancer Institute, 2012,Volume: 104,Issue: 20,Page: 1576-1590
Authors:  Shim J.S.;  Rao R.;  Beebe K.;  Neckers L.;  Han I.;  Nahta R.;  Liu J.O.
Favorite | View/Download:8/0 | TC[WOS]:52 TC[Scopus]:0 | Submit date:2019/01/15
Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation Journal article
Proceedings of the National Academy of Sciences of the United States of America, 2011,Volume: 108,Issue: 48,Page: 19264-19269
Authors:  Rovira M.;  Huang W.;  Yusuff S.;  Shim J.S.;  Ferrante A.A.;  Liu J.O.;  Parsons M.J.
Favorite | View/Download:6/0 | TC[WOS]:60 TC[Scopus]:0 | Submit date:2019/01/15
Development  Embryogenesis  Notch-signaling  Progenitor