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Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
ACS Chemical Biology, 2017,Volume: 12,Issue: 1,Page: 174
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.;  Pasunooti K.K.;  Li R.-J.;  Shim J.S.;  Liu J.O.
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Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Cho Y.S.;  Yen C.-N.;  Shim J.S.;  Kang D.H.;  Kang S.W.;  Liu J.O.;  Kwon H.J.
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Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Clinical Cancer Research, 2016,Volume: 22,Issue: 11,Page: 2709-2720
Authors:  Shim J.S.;  Li R.-J.;  Bumpus N.N.;  Head S.A.;  Pasunooti K.K.;  Yang E.J.;  Lv J.;  Shi W.;  Liu J.O.
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Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors Journal article
ACS Medicinal Chemistry Letters, 2015,Volume: 6,Issue: 7,Page: 782-786
Authors:  He R.;  Yu Z.-H.;  Zhang R.-Y.;  Wu L.;  Gunawan A.M.;  Lane B.S.;  Shim J.S.;  Zeng L.-F.;  He Y.;  Chen L.;  Wells C.D.;  Liu J.O.;  Zhang Z.-Y.
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anticancer agents  fragment-based library  Protein tyrosine phosphatase  pTyr mimetics  SHP2 inhibitors  
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Proceedings of the National Academy of Sciences of the United States of America, 2015,Volume: 112,Issue: 52,Page: E7276
Authors:  Head S.A.;  Shi W.;  Zhao L.;  Gorshkov K.;  Pasunooti K.;  Chen Y.;  Deng Z.;  Li R.-J.;  Shim J.S.;  Tan W.;  Hartung T.;  Zhang J.;  Zhao Y.;  Colombini M.;  Liu J.O.
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Angiogenesis  Itraconazole  Metabolism  Mitochondria  VDAC1  
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass Journal article
eLife, 2015,Volume: 4,Issue: 2015-07-01
Authors:  Wang G.;  Rajpurohit S.K.;  Delaspre F.;  Walker S.L.;  White D.T.;  Ceasrine A.;  Kuruvilla R.;  Li R.-J.;  Shim J.S.;  Liu J.O.;  Parsons M.J.;  Mumm J.S.
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Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism Journal article
Cancer Letters, 2015,Volume: 362,Issue: 1,Page: 106-115
Authors:  Shim J.S.;  Li R.-J.;  Lv J.;  Head S.A.;  Yang E.J.;  Liu J.O.
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Angiogenesis  Cholesterol Trafficking  Selective Estrogen Receptor Modulator  Tamoxifen  
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
British Journal of Pharmacology, 2014,Volume: 171,Issue: 19,Page: 4478-4489
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.;  Das M.;  Liu J.O.
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Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression Journal article
Oncology Reports, 2014,Volume: 32,Issue: 1,Page: 419-424
Authors:  Wissing M.D.;  Dadon T.;  Kim E.;  Piontek K.B.;  Shim J.S.;  Kaelber N.S.;  Liu J.O.;  Kachhap S.K.;  Nelkin B.D.
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Cyclin-dependent kinase 5  Prostate cancer  Synthetic lethality  Tilorone  
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells Journal article
Journal of Medicinal Chemistry, 2013,Volume: 56,Issue: 10,Page: 3996-4016
Authors:  Zhang F.;  Bhat S.;  Gabelli S.B.;  Chen X.;  Miller M.S.;  Nacev B.A.;  Cheng Y.L.;  Meyers D.J.;  Tenney K.;  Shim J.S.;  Crews P.;  Amzel L.M.;  Ma D.;  Liu J.O.
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