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| Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics Journal article
Food Chemistry, 2020,Volume: 327
Authors: Zhang，Le Le; Huang，Mu Yang; Yang，Yong; Huang，Ming Qing; Shi，Jia Jie; Zou，Liang; Lu，Jin Jian
  Favorite | View/Download：0/0 | TC[WOS]:2 TC[Scopus]:1 | Submit date：2021/03/02
Pharmacokinetics Pharmacological activities Phytochemistry Platycodins Platycodonis Radix Toxicology |
| Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics Journal article
Food Chemistry, 2020,Volume: 327
Authors: Zhang，Le Le; Huang，Mu Yang; Yang，Yong; Huang，Ming Qing; Shi，Jia Jie; Zou，Liang; Lu，Jin Jian
Favorite | View/Download：0/0 | TC[WOS]:2 TC[Scopus]:1 | Submit date：2021/03/02
Pharmacokinetics Pharmacological activities Phytochemistry Platycodins Platycodonis Radix Toxicology |
| Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells Journal article
Chinese Journal of Natural Medicines, 2020,Volume: 18,Issue: 7,Page: 517-525
Authors: CHEN，Yu Chi; HUANG，Mu Yang; ZHANG，Le Le; FENG，Zhe Ling; JIANG，Xiao Ming; YUAN，Luo Wei; HUANG，Run Yue; LIU，Bo; YU，Hua; WANG，Yi Tao; CHEN，Xiu Ping; LIN，Li Gen; LU，Jin Jian
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c-Jun JNK Lung cancer Nagilactone E Programmed death ligand 1 |
| Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus Journal article
Biochemical Pharmacology, 2020,Volume: 175
Authors: Li，Ting; Xu，Xiao Huang; Guo，Xia; Yuan，Tao; Tang，Zheng Hai; Jiang，Xiao Ming; Xu，Yu Lian; Zhang，Le Le; Chen，Xiuping; Zhu，Hong; Shi，Jia Jie; Lu，Jin Jian
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Apoptosis c-MYC CHOP Lung cancer Notch 3 |
| Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors: Zhang，Le le; Guo，Jing; Jiang，Xiao ming; Chen，Xiu ping; Wang，Yi tao; Li，Ao; Lin，Li gen; Li，Hua; Lu，Jin jian
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Click-iT CMap diterpenoids human lung cancer A549 cell line xenograft molecular docking nagilactone E protein synthesis inhibitor RIOK2 RNA-seq |
| Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway Journal article
Toxicology and Applied Pharmacology, 2020,Volume: 389
Authors: Li，Ao; Xiao，Xiao; Feng，Zhe Ling; Chen，Xiuping; Liu，Li Juan; Lin，Li Gen; Lu，Jin Jian; Zhang，Le Le
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Bleomycin Fibrotic process Nagilactone D Pulmonary fibrosis TGF-β1 |
| TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance Journal article
Acta Pharmacologica Sinica, 2020
Authors: Jiang，Xiao ming; Xu，Yu lian; Yuan，Luo wei; Zhang，Le le; Huang，Mu yang; Ye，Zi han; Su，Min xia; Chen，Xiu ping; Zhu，Hong; Ye，Richard D.; Lu，Jin jian
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EGFR mutant non-small cell lung cancer epithelial-mesenchymal transition NF-κB osimertinib resistance TGFβ2 |
| Phanginin R induces cytoprotective autophagy via JNK/C-JUN signaling pathway in non-small cell lung cancer A549 cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2020,Volume: 20,Issue: 8,Page: 982-988
Authors: Zhang，Le Le; Bao，Han; Xu，Yu Lian; Jiang，Xiao Ming; Li，Wei; Zou，Liang; Lin，Li Gen; Lu，Jin Jian
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Anti-cancer Autophagy C-Jun JNK Non-small cell lung cancer Phanginin R |
| Nagilactone E suppresses TGF-beta 1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell lung cancer cells Journal article
PHYTOMEDICINE, 2019,Volume: 52,Page: 32-39
Authors: Le-Le Zhang; Xiao-Ming Jiang; Mu-Yang Huang; Zhe-Ling Feng; Xiuping Chen; Yitao Wang; Hua Li; Ao Li; Li-Gen Lin; Jin-Jian Lu
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Nagilactone e Tgf-β1 Epithelial-mesenchymal Transitio Smad |
| Establishment and characterization of pemetrexed-resistant NCI-H460/PMT cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2019,Volume: 19,Issue: 6,Page: 731-739
Authors: Xu，Yu Lian; Jiang，Xiao Ming; Zhang，Le Le; Chen，Xiuping; Huang，Zhang Jian; Lu，Jin Jian
Favorite | View/Download：0/0 | TC[WOS]:2 TC[Scopus]:2 | Submit date：2021/03/01
ABCB1 Chemotherapy NSCLC Pemetrexed Resistance TYMS |
