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Discovery, synthesis, and functional characterization of a novel neuroprotective natural product from the fruit of alpinia oxyphylla for use in Parkinson's disease through LC/MS-based multivariate data analysis-guided fractionation Journal article
Journal of Proteome Research, 2016,Volume: 15,Issue: 8,Page: 2595-2606
Authors:  Li G.;  Zhang Z.;  Quan Q.;  Jiang R.;  Szeto S.S.W.;  Yuan S.;  Wong W.-T.;  Lam H.H.C.;  Lee S.M.-Y.;  Chu I.K.
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natural products  neuroprotective  NRF2  Parkinson's disease  proteomics  
A versatile reversed phase-strong cation exchange-reversed phase (RP-SCX-RP) multidimensional liquid chromatography platform for qualitative and quantitative shotgun proteomics Journal article
Analyst, 2015,Volume: 140,Issue: 4,Page: 1237-1252
Authors:  Law H.C.H.;  Kong R.P.W.;  Szeto S.S.W.;  Zhao Y.;  Zhang Z.;  Wang Y.;  Li G.;  Quan Q.;  Lee S.M.Y.;  Lam H.C.;  Chu I.K.
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Proteomic Profiling of 6-Hydroxydopaminetreated Zebrafish using Itraq-2D LC-MS/MS analysis Book
2014
Authors:  Wang Lei B.U.;  Yu N.;  Zhang Z.-J.;  Lau E.;  Siu S.O.;  Lam M.P.Y.;  Li G.-H.;  Chu I.K.;  Lee S.M.-Y.
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Fully automatable two-dimensional hydrophilic interaction liquid chromatography-reversed phase liquid chromatography with online tandem mass spectrometry for shotgun proteomics Journal article
Journal of Separation Science, 2012,Volume: 35,Issue: 14,Page: 1755
Authors:  Zhao Y.;  Kong R.P.W.;  Li G.;  Lam M.P.Y.;  Law C.H.;  Lee S.M.Y.;  Lam H.C.;  Chu I.K.
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HILIC-RP  Orthogonality  Proteomics  Two-dimensional liquid chromatography  
In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent Journal article
Molecular Nutrition and Food Research, 2012,Volume: 56,Issue: 6,Page: 945
Authors:  Lam I.K.;  Alex D.;  Wang Y.-H.;  Liu P.;  Liu A.-L.;  Du G.-H.;  Yuen Lee S.M.
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Angiogenesis  Polymethoxylated Flavonoid  Sinensetin  Structure-activity Relationship  Zebrafish  
Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics Journal article
Proteomics, 2011,Volume: 11,Issue: 11,Page: 2308-2319
Authors:  Siu S.O.;  Lam M.P.Y.;  Lau E.;  Kong R.P.W.;  Lee S.M.Y.;  Chu I.K.
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Lc-ms/ms  Multidimensional Lc  Protein Profile  Technology  
Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model Journal article
Journal of Cellular Biochemistry, 2011,Volume: 112,Issue: 11,Page: 3313
Authors:  Lam K.H.;  Alex D.;  Lam I.K.;  Tsui S.K.W.;  Yang Z.F.;  Lee S.M.Y.
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Angiogenesis  Anti-inflammatory  Cell Cycle  Flavonoid  Nobiletin  Zebrafish  
Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model Journal article
Journal of Ethnopharmacology, 2010,Volume: 131,Issue: 2,Page: 242
Authors:  Alex D.;  Lam I.K.;  Lin Z.;  Lee S.M.Y.
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Anti-angiogenesis  Apoptosis  Indirubin  Zebrafish