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Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
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Sodium tanshinone IIA sulfonate  Salvia miltiorrhiza  Hemorrhagic stroke  Atorvastatin  ROCK  
Sichuan pepper attenuates H2O2-induced apoptosis via antioxidant activity and up-regulating heme oxygenase-1 gene expression in primary rat hepatocytes Journal article
JOURNAL OF FOOD BIOCHEMISTRY, 2017,Volume: 41,Issue: 6
Authors:  Zhang, Huan;  Zhou, Xuelin;  Wong, Marcus Ho-Yin;  Man, Ka-Yi;  Pin, Wing-Kwan;  Yeung, John Hok-Keung;  Kwan, Yiu-Wa;  Leung, George Pak-Heng;  Hoi, Pui-Man;  Lee, Simon Ming-Yuen;  Chan, Chi-On;  Mok, Daniel Kam-Wah;  Yu, Peter Hoi-Fu;  Chan, Shun-Wan
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liver  reactive oxygen species  Rutaceae  Zanthoxylum bungeanum Maxim  
Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics Journal article
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2017,Volume: 31,Issue: 11
Authors:  Chan, Judy Yuet-Wa;  Zhou, Hefeng;  Kwan, Yiu Wa;  Chan, Shun Wan;  Radis-Baptista, Gandhi;  Lee, Simon Ming-Yuen
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acute toxicity  rhodamine B-crotamine  screening of pharmaceuticals  venom-derived peptides  zebrafish model  
Lysosomal Ca2+ Signaling REgulates High Glucose-Mediated Interleukin-1 beta Secretion via Transcription Factor EB in Human Monocytic Cells Journal article
FRONTIERS IN IMMUNOLOGY, 2017,Volume: 8
Authors:  Tseng, Hisa Hui Ling;  Vong, Chi Teng;  Kwan, Yiu Wa;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui Man
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high glucose  lysosomal Ca2+  Ca2+ homeostasis  lysosomal exocytosis  interleukin-1 beta  monocytes  
Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae Journal article
MOLECULAR BIOSYSTEMS, 2011,Volume: 7,Issue: 7,Page: 2128-2138
Authors:  Li, ZH (Li, Zhen Hua);  Alex, D (Alex, Deepa);  Siu, SO (Siu, Shiu On);  Chu, IK (Chu, Ivan Keung);  Renn, J (Renn, Joerg);  Winkler, C (Winkler, Christoph);  Lou, S (Lou, Shaoke);  Tsui, SKW (Tsui, Stephen Kwok-Wing);  Zhao, HY (Zhao, Hai Yu);  Yan, WR (Yan, Wendy Ru);  Mahady, GB (Mahady, Gail B.);  Li, GH (Li, Guo Hui);  Kwan, YW (Kwan, Yiu Wa);  Wang, YT (Wang, Yi Tao);  Lee, SMY (Lee, Simon Ming-Yuen)
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Animal-models  Flavonoids  Quercetin  Bone  Fluorescence  Absorption  Proteome  Swim