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Anti-neuroinflammatory effects of SLOH in A beta-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3 beta Journal article
NEUROSCIENCE LETTERS, 2018,Volume: 687,Page: 207-215
Authors:  Wu, Xiaoli;  Kosaraju, Jayasankar;  Tam, Kin Yip
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SLOH  BV-2 cells  3xTg-AD mice  Neuroinflammation  GSK-3 beta  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
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Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
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Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Editorial, IAPC-6 Meeting Journal article
PHARMACEUTICAL RESEARCH, 2018,Volume: 35,Issue: 11
Authors:  Tam, Kin;  Li, Tonglei;  Mandic, Zoran
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Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
Favorite  |  View/Download:6/0  |  Submit date:2018/10/30
aerobic glycolysis  AZD7545  dichloroacetate  LC-MS/MS  pyruvate dehydrogenase kinases  cancer metabolism  
Two dimensional photoacoustic imaging using microfiber interferometric acoustic transducers Journal article
OPTICS COMMUNICATIONS, 2018,Volume: 419,Page: 41-46
Authors:  Wang, Xiu Xin;  Li, Zhang Yong;  Tian, Yin;  Wang, Wei;  Pang, Yu;  Tam, Kin Yip
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Fiber Optics  Fiber Bragg Gratings  Micro-optical Devices  Photoacoustic Imaging  
Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors Journal article
DRUG DISCOVERY TODAY, 2018,Volume: 23,Issue: 7,Page: 1407-1415
Authors:  Zhang, Shao-Lin;  He, Yun;  Tam, Kin Yip
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Identification of a Wells-Dawson polyoxometalate-based AP-2 gamma inhibitor with pro-apoptotic activity Journal article
BIOCHEMICAL JOURNAL, 2018,Volume: 475,Issue: 11,Page: 1965-1977
Authors:  Hu, Jiamiao;  Tan, Si Kee;  Lim, Michelle Gek Liang;  Chang, Shie Hong;  Cui, Guimei;  Liu, Shanshan;  Narasimhan, Kamesh;  New, Siu Yee;  Wang, Xuecong;  Chen, Congling;  Chakravarty, Harapriya;  Kolatkar, Prasanna R.;  Tam, Kin Yip;  Lu, Qian;  Su, Xiaodi;  Jauch, Ralf;  Cheung, Edwin
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
Ap-2γ  Breast Cancer  Fluorescent Anisotropic  Polyoxometalate  
The Scalp Time-Varying Networks of N170: Reference, Latency, and Information Flow Journal article
FRONTIERS IN NEUROSCIENCE, 2018,Volume: 12
Authors:  Tian, Yin;  Xu, Wei;  Zhang, Huiling;  Tam, Kin Y.;  Zhang, Haiyong;  Yang, Li;  Li, Zhangyong;  Pang, Yu
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
N170  Time-varying Network  Rest  Ar  Latency