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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite | View/Download:76/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite | View/Download:73/0 | TC[WOS]:0 TC[Scopus]:1 | Submit date:2020/09/16
BRCA1  Breast cancer  DNA damage  HDAC  Histone deacetylase  Reactive oxygen species  Synthetic lethality  
Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 Journal article
NATURE METHODS, 2019,Volume: 16,Issue: 8,Page: 722–730
Authors:  Gigi C. G. Choi;  Peng Zhou;  Chaya T. L. Yuen;  Becky K. C. Chan;  Feng Xu;  Siyu Bao;  Hoi Yee Chu;  Dawn Thean;  Kaeling Tan;  Koon Ho Wong;  Zongli Zheng;  Alan S. L. Wong
Favorite | View/Download:15/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2020/05/21
Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi Journal article
FUNGAL GENETICS AND BIOLOGY, 2019,Volume: 125,Page: 28-35
Authors:  Longguang Qin;  Ang Li;  Kaeling Tan;  Shuhui Guo;  Yingying Chen;  Fang Wang;  Koon Ho Wong
Favorite | View/Download:8/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/05/21
Gene Deletion  Epitope Tagging  Selectable Markers  Plasmid Collection  Filamentous Fungi  Aspergillus  
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite | View/Download:31/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/12/17
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space Journal article
PLOS GENETICS, 2018,Volume: 14,Issue: 3
Authors:  Veri, Amanda O.;  Miao, Zhengqiang;  Shapiro, Rebecca S.;  Tebbji, Faiza;  O'Meara, Teresa R.;  Kim, Sang Hu;  Colazo, Juan;  Tan, Kaeling;  Vyas, Valmik K.;  Whiteway, Malcolm;  Robbins, Nicole;  Wong, Koon Ho;  Cowen, Leah E.
Favorite | View/Download:48/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2018/10/30
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A Journal article
CANCER LETTERS, 2018,Volume: 436,Page: 28-37
Authors:  Yifan Liu;  Eun Ju Yang;  Baoyuan Zhang;  Zhengqiang Miao;  Changjie Wu;  Junfang Lyu;  Kaeling Tan;  Terence Chuen Wai Poon;  Joong Sup Shim
Favorite | View/Download:30/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/10/30
Akt  Kw2449  Synthetic Lethality  Aurka  Drug Combination  
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation Journal article
NATURE COMMUNICATIONS, 2017,Volume: 8
Authors:  Xie, Jinglin L.;  Qin, Longguang;  Miao, Zhengqiang;  Grys, Ben T.;  Diaz, Jacinto De La Cruz;  Ting, Kenneth;  Krieger, Jonathan R.;  Tong, Jiefei;  Tan, Kaeling;  Leach, Michelle D.;  Ketela, Troy;  Moran, Michael F.;  Krysan, Damian J.;  Boone, Charles;  Andrews, Brenda J.;  Selmecki, Anna;  Wong, Koon Ho;  Robbins, Nicole;  Cowen, Leah E.
Favorite | View/Download:24/0 | TC[WOS]:16 TC[Scopus]:0 | Submit date:2018/10/30
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans Journal article
Nature Communications, 2016,Volume: 7
Authors:  Michelle D. Leach;  Rhys A. Farrer;  Kaeling Tan;  Zhengqiang Miao;  Louise A. Walker;  Christina A. Cuomo;  Robert T. Wheeler;  Alistair J. P. Brown;  Koon Ho Wong;  Leah E. Cowen
Favorite | View/Download:9/0 | TC[WOS]:34 TC[Scopus]:0 | Submit date:2019/01/16
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodeling and chromatin architecture in Candida albicans Journal article
NATURE COMMUNICATIONS, 2016,Volume: 7
Authors:  Michelle D. Leach;  Rhys A. Farrer;  Kaeling Tan;  Zhengqiang Miao;  Louise A. Walker;  Christina A. Cuomo;  Robert T. Wheeler;  Alistair J. P. Brown;  Koon Ho Wong;  Leah E. Cowen
Favorite | View/Download:9/0 | TC[WOS]:34 TC[Scopus]:0 | Submit date:2019/01/21