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Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library Journal article
Journal of Medicinal Chemistry, 2019,Volume: 62,Issue: 6,Page: 2928-2937
Authors:  Shaikh F.;  Zhao Y.;  Alvarez L.;  Iliopoulou M.;  Lohans C.;  Schofield C.J.;  Padilla-Parra S.;  Siu S.W.I.;  Fry E.E.;  Ren J.;  Stuart D.I.
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Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
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Drug repurposing  Mitoxantrone  NEDD8  Ubiquitin  
Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors Journal article
Journal of Medicinal Chemistry, 2017,Volume: 60,Issue: 13,Page: 5927-5932
Authors:  Chang Y.;  Lu X.;  Shibu M.A.;  Dai Y.-B.;  Luo J.;  Zhang Y.;  Li Y.;  Zhao P.;  Zhang Z.;  Xu Y.;  Tu Z.-C.;  Zhang Q.-W.;  Yun C.-H.;  Huang C.-Y.;  Ding K.
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Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors Journal article
JOURNAL OF MEDICINAL CHEMISTRY, 2017,Volume: 60,Issue: 13,Page: 5927-5932
Authors:  Chang, Yu;  Lu, Xiaoyun;  Shibu, Marthandam Asokan;  Dai, Yi-Bo;  Luo, Jinfeng;  Zhang, Yan;  Li, Yingjun;  Zhao, Peng;  Zhang, Zhang;  Xu, Yong;  Tu, Zheng-Chao;  Zhang, Qing-Wen;  Yun, Cai-Hong;  Huang, Chih-Yang;  Ding, Ke
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A Rhodium(III)-Based Inhibitor of Lysine-Specific Histone Demethylase 1 as an Epigenetic Modulator in Prostate Cancer Cells Journal article
JOURNAL OF MEDICINAL CHEMISTRY, 2017,Volume: 60,Issue: 6,Page: 2597-2603
Authors:  Yang, Chao;  Wang, Wanhe;  Liang, Jia-Xin;  Li, Guodong;  Vellaisamy, Kasipandi;  Wong, Chun-Yuen;  Ma, Dik-Lung;  Leung, Chung-Hang
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An Orally Active Bradykinin B-1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor Journal article
JOURNAL OF MEDICINAL CHEMISTRY, 2017,Volume: 60,Issue: 1,Page: 504-510
Authors:  Qiu, Yibo;  Taichi, Misako;  Wei, Na;  Yang, Huan;  Luo, Kathy Qan;  Tam, James P.
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A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease Journal article
JOURNAL OF MEDICINAL CHEMISTRY, 2017,Volume: 60,Issue: 1,Page: 497-503
Authors:  Zhong, Hai-Jing;  Wang, Wanhe;  Kang, Tian-Shu;  Yan, Hui;  Yang, Yali;  Xu, Lipeng;  Wang, Yuqiang;  Ma, Dik-Lung;  Leung, Chung-Hang
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An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor Journal article
Journal of Medicinal Chemistry, 2017,Volume: 60,Issue: 1,Page: 504-510
Authors:  Qiu Y.;  Taichi M.;  Wei N.;  Yang H.;  Luo K.Q.;  Tam J.P.
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Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 7,Page: 3562-3568
Authors:  Zhang S.-L.;  Hu X.;  Zhang W.;  Tam K.Y.
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Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 8,Page: 4026
Authors:  Kang T.-S.;  Mao Z.;  Ng C.-T.;  Wang M.;  Wang W.;  Wang C.;  Lee S.M.-Y.;  Wang Y.;  Leung C.-H.;  Ma D.-L.
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