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Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells Journal article
NATURE COMMUNICATIONS, 2018,Volume: 9
Authors:  Wu, Changjie;  Lyu, Junfang;  Yang, Eun Ju;  Liu, Yifan;  Zhang, Baoyuan;  Shim, Joong Sup
Favorite  |  View/Download:13/0  |  Submit date:2018/10/30
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite  |  View/Download:11/0  |  Submit date:2018/12/17
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A Journal article
CANCER LETTERS, 2018,Volume: 436,Page: 28-37
Authors:  Liu, Yifan;  Yang, Eun Ju;  Zhang, Baoyuan;  Miao, Zhengqiang;  Wu, Changjie;  Lyu, Junfang;  Tan, Kaeling;  Poon, Terence Chuen Wai;  Shim, Joong Sup
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Akt  Kw2449  Synthetic Lethality  Aurka  Drug Combination  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Chakravarty, Harapriya;  Zhang, Shaolin;  Tam, Kin Yip;  Dang, Yongjun;  Kwon, Ho Jeong;  Gel, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite  |  View/Download:17/0  |  Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor  
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth Journal article
CANCER LETTERS, 2017,Volume: 409,Page: 91-103
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Yang, Chen;  Dang, Yongjun;  Kwon, Ho Jeong;  Ge, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Tumor  Lysosome  Cepharanthine  
Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis Journal article
ACS CHEMICAL BIOLOGY, 2017,Volume: 12,Issue: 1,Page: 174-182
Authors:  Head, Sarah A.;  Shi, Wei Q.;  Yang, Eun Ju;  Nacev, Benjamin A.;  Hong, Sam Y.;  Pasunooti, Kalyan K.;  Li, Ruo-Jing;  Shim, Joong Sup;  Liu, Jun O.
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Revisiting Non-Cancer Drugs for Cancer Therapy Journal article
Current Topics in Medicinal Chemistry, 2016,Volume: 16,Issue: 19,Page: 2144-2155
Authors:  Yang E.J.;  Wu C.;  Liu Y.;  Lv J.;  Shim J.S.
Favorite  |  View/Download:4/0  |  Submit date:2019/01/15
Cancer  Disulfiram  Doxycycline  Drug Repositioning  Existing Drugs  Mebendazole  Pyrvinium Pamoate  Triclosan  
Targeting epithelial-mesenchymal transition (EMT) to overcome drug resistance in cancer Journal article
MOLECULES, 2016,Volume: 21,Issue: 7
Authors:  Bowen Du;  Joong Sup Shim
Favorite  |  View/Download:1/0  |  Submit date:2019/01/24
Epithelial–mesenchymal Transition  Drug Resistance  Chemotherapy  Cancer Stem Cells  
Divergence of anti-angiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Clinical Cancer Research, 2016,Volume: 22,Issue: 11,Page: 2709-2720
Authors:  Joong Sup Shim;  Ruo-Jing Li;  Namandje N. Bumpus;  Sarah A. Head;  Kalyan Kumar;  Eun Ju Yang;  Junfang Lv;  Wei Shi;  Jun O. Liu
Favorite  |  View/Download:2/0  |  Submit date:2019/01/24
Itraconazole  Stereoisomers  Drug Repositioning  Angiogenesis  Hepatotoxicity  
The small molecule R-(-)-β-O-methylsynephrine binds to nucleoporin 153 kDa and inhibits angiogenesis Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 9,Page: 1088-1099
Authors:  Kim N.H.;  Pham N.B.;  Quinn R.J.;  Shim J.S.;  Cho H.;  Cho S.M.;  Park S.W.;  Kim J.H.;  Seok S.H.;  Oh J.-W.;  Kwon H.J.
Favorite  |  View/Download:3/0  |  Submit date:2019/01/15
Angiogenesis  Natural Product  Nup153  Small Molecule  Target Identification