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Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus Journal article
Biochemical Pharmacology, 2020,Volume: 175
Authors:  Li,Ting;  Xu,Xiao Huang;  Guo,Xia;  Yuan,Tao;  Tang,Zheng Hai;  Jiang,Xiao Ming;  Xu,Yu Lian;  Zhang,Le Le;  Chen,Xiuping;  Zhu,Hong;  Shi,Jia Jie;  Lu,Jin Jian
Favorite | View/Download:0/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/01
Apoptosis  c-MYC  CHOP  Lung cancer  Notch 3  
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:  Zhang,Le le;  Guo,Jing;  Jiang,Xiao ming;  Chen,Xiu ping;  Wang,Yi tao;  Li,Ao;  Lin,Li gen;  Li,Hua;  Lu,Jin jian
Favorite | View/Download:0/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/01
Click-iT  CMap  diterpenoids  human lung cancer A549 cell line xenograft  molecular docking  nagilactone E  protein synthesis inhibitor  RIOK2  RNA-seq  
MLKL mediates apoptosis via a mutual regulation with PERK/eIF2 alpha pathway in response to reactive oxygen species generation Journal article
APOPTOSIS, 2018,Volume: 23,Issue: 9-10,Page: 521-531
Authors:  Wen‑Xiang Cao;  Ting Li;  Zheng‑Hai Tang;  Le‑Le Zhang;  Zhao‑Yu Wang;  Xia Guo;  Min‑Xia Su;  Xiuping Chen;  Jin‑Jian Lu
Favorite | View/Download:18/0 | TC[WOS]:1 TC[Scopus]:2 | Submit date:2020/01/09
Mlkl  Eif2α  Ros  Apoptosis  Chelerythrine  
Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer Journal article
CANCER LETTERS, 2018,Volume: 412,Page: 1-9
Authors:  Tang, Zheng-Hai;  Cao, Wen-Xiang;  Guo, Xia;  Dai, Xiao-Yang;  Lu, Jia-Hong;  Chen, Xiuping;  Zhu, Hong;  Lu, Jin-Jian
Favorite | View/Download:47/0 | TC[WOS]:15 TC[Scopus]:17 | Submit date:2018/10/30
Cepharanthine  Autophagy  Lysosome  Dacomitinib  Nsclc  
Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2018,Volume: 18,Issue: 4,Page: 550-555
Authors:  Tang Z.-H.;  Su M.-X.;  Guo X.;  Jiang X.-M.;  Jia L.;  Chen X.;  Lu J.-J.
Favorite | View/Download:14/0 | TC[WOS]:4 TC[Scopus]:7 | Submit date:2018/12/28
Azd9291  Egfr  Ire1α  Lune Cancer  Nsclc  Osimertinib  
Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells Journal article
PLANTA MEDICA, 2017,Volume: 83,Issue: 3-4,Page: 254-260
Authors:  Xu, Xiao-Huang;  Zhang, Le-Le;  Wu, Guo-Sheng;  Chen, Xin;  Li, Ting;  Chen, Xiuping;  Wang, Yi-Tao;  Lu, Jin-Jian
Favorite | View/Download:34/0 | TC[WOS]:8 TC[Scopus]:8 | Submit date:2018/10/30
Ovarian Cancer  Solasodine  Apoptosis  Autophagy  Migration  Invasion  
Fangchinoline accumulates autophagosomes by inhibiting autophagic degradation and promoting TFEB nuclear translocation Journal article
RSC ADVANCES, 2017,Volume: 7,Issue: 67,Page: 42597-42605
Authors:  Tang, Zheng-Hai;  Guo, Xia;  Cao, Wen-Xiang;  Chen, Xiuping;  Lu, Jin-Jian
Favorite | View/Download:35/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/10/30
Chemical constituents and biological research on plants in the genus Curcuma Journal article
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2017,Volume: 57,Issue: 7,Page: 1451-1523
Authors:  Sun, Wen;  Wang, Sheng;  Zhao, Wenwen;  Wu, Chuanhong;  Guo, Shuhui;  Gao, Hongwei;  Tao, Hongxun;  Lu, Jinjian;  Wang, Yitao;  Chen, Xiuping
Favorite | View/Download:33/0 | TC[WOS]:22 TC[Scopus]:29 | Submit date:2018/10/30
Genus Curcuma  Chemical Constituents  Bioactivities  Antitumor  
Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells Journal article
Journal of Drug Targeting, 2016,Volume: 24,Issue: 10,Page: 934-942
Authors:  Shuhui Guo;  Weiwei Luo;  Lijuan Liu;  Xiaocong Pang;  Hong Zhu;  Ailin Liu;  Jinjian Lu;  Dik-Lung Ma;  Chung-Hang Leung;  Yitao Wang;  Xiuping Chen
Favorite | View/Download:16/0 | TC[WOS]:18 TC[Scopus]:25 | Submit date:2018/10/31
Apoptosis  Autophagy  Isocryptotanshinone  Stat3  
Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line Journal article
Oncotarget, 2016,Volume: 7,Issue: 49,Page: 81598-81610
Authors:  Tang Z.-H.;  Jiang X.-M.;  Guo X.;  Fong C.M.V.;  Chen X.;  Lu J.-J.
Favorite | View/Download:16/0 | TC[WOS]:27 TC[Scopus]:28 | Submit date:2018/12/28
Azd9291  Egfr  Navitoclax  Nsclc  Osimertinib