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A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Alzheimer's disease  tetramethylpyrazine derivative  NMDA receptor  neuroprotection  oxidative stress  GSK3 beta  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
Favorite  |  View/Download:7/0  |  Submit date:2018/10/30
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View  |  Adobe PDF(2766Kb)  |  Favorite  |  View/Download:100/4  |  Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui;  Mak, Shinghung;  Hu, Shengquan;  Sun, Hongya;  Wu, Xiang;  Zhang, Zaijun;  Lee, Mingyuen;  Tsim, Wahkeung;  Su, Wei;  Zhou, Wenhua;  Cui, Wei;  Han, Yifan;  Wang, Qinwen
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Indirubin-3-oxime  H2O2  GSK3 beta  PI3-K  ERK  
Bis(12)-hupyridone, a promising multi-functional anti-Alzheimer’s dimer derived from Chinese medicine Book chapter
出自: When Things Go Wrong - Diseases and Disorders of the Human Brain:InTech, 2012
Authors:  Wei Cui;  Tony Chung-Lit Choi;  Shinghung Mak;  Hua Yu;  Shengquan Hu;  Wenming Li;  Zhong Zuo
Favorite  |  View/Download:0/0  |  Submit date:2019/01/25
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR Journal article
BRAIN RESEARCH, 2011,Volume: 1401,Issue: 15,Page: 10-17
Authors:  Cui, Wei;  Cui, Guo-Zhen;  Li, Wenming;  Zhang, Zaijun;  Hu, Shengquan;  Mak, Shinghung;  Zhang, Huan;  Carlier, Paul R.;  Choi, Chung-lit;  Wong, Yi-Tao;  Lee, Simon Ming-Yuen;  Han, Yifan
Favorite  |  View/Download:3/0  |  Submit date:2018/11/01
Bis(12)-hupyridone  Huperzine a  Neural Stem Cell  Neurodegenerative Disorder  Differentiation  Alpha 7nachr