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A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Xinhua Zhou;  Anqi Wang;  Liang Wang;  Jianhua Yin;  Li Wang;  Lijun Di;  Maggie Pui-Man Hoi;  Luchen Shan;  Xu Wu;  Yuqiang Wang
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Danshensu  Tetramethylpyrazine  Breast Cancer  Resistance  Glycolysis  P-glycoprotein  
Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
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Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction Journal article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018,Volume: 66,Issue: 31,Page: 8307-8318
Authors:  Li, Chuwen;  Tang, Benqin;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  Su, Ziren;  Lee, Simon Ming-Yuen
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Pinostrobin  Parkinson's Disease  Neurotoxin  Nrf2  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
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Cardioprotection  Anti-oxidative stress  Anti-apoptosis  Autophagy regulation  Zebrafish cardiotoxicity  H9c2 cardiomyocytes  
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 128,Page: 389-398
Authors:  Huang, Bin;  Zhou, Zhong-Yan;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
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Tanshinone I  Vascular integrity  Endothelial cell adhesion  Hemorrhagic stroke  Zebrafish  HUVECs  
Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza) Journal article
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018
Authors:  Zou, Jia;  Chen, Yang;  Hoi, Maggie Pui Man;  Li, Jun;  Wang, Tao;  Zhang, Ying;  Feng, Yu;  Gao, Jianli;  Lee, Simon Ming Yuen;  Cui, Guozhen
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Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation Journal article
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Zhang, Chao;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  He, Chengwei;  Zheng, Ying;  Lee, Simon Ming-Yuen
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Schisantherin a  Neuroinflammation  Microglia  Nrf2  Nf-kappa b  
Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells Journal article
PLANT JOURNAL, 2017,Volume: 92,Issue: 3,Page: 452-468
Authors:  Hisa Hui Ling Tseng;  Chi Teng Vong;  Yiu Wa Kwan;  Simon Ming Yuen Lee;  Maggie Pui Man Hoi
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High Glucose  Lysosomal Ca2++++  Ca2++++ Homeostasis  Lysosomal Exocytosis  Interleukin-1β  Monocytes  
Lysosomal Ca2+ Signaling REgulates High Glucose-Mediated Interleukin-1 beta Secretion via Transcription Factor EB in Human Monocytic Cells Journal article
FRONTIERS IN IMMUNOLOGY, 2017,Volume: 8
Authors:  Tseng, Hisa Hui Ling;  Vong, Chi Teng;  Kwan, Yiu Wa;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui Man
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high glucose  lysosomal Ca2+  Ca2+ homeostasis  lysosomal exocytosis  interleukin-1 beta  monocytes  
An andrographolide derivative AGP-26b exibitiing anti-angiogenic activity in HUVECs and zebrafish via blocking the VEGFA/VEGFR2 signaling pathway Journal article
MOLECULAR BIOSYSTEMS, 2017,Volume: 13,Issue: 3,Page: 525-536
Authors:  Huang, Bin;  Peng, Yuran;  Li, Jingjing;  Li, Shang;  Sun, Yicheng;  Wang, Decai;  Yang, Binrui;  Chan, Judy Yuet-Wa;  Yu, Huidong;  Leung, George Pak-Heng;  Hoi, Maggie Pui-Man;  Zhou, Guo-Chun;  Lee, Simon Ming-Yuen
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