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Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 8,Page: 1450-1462
Authors:  Zhong,Hui;  Ren,Zhili;  Wang,Xiaoyan;  Miao,Kai;  Ni,Wenjun;  Meng,Ya;  Lu,Ligong;  Wang,Chunming;  Liu,Weiwei;  Deng,Chu Xia;  Xu,Ren He;  Chen,Guokai
Favorite  |  View/Download:1/0  |  Submit date:2020/09/16
Defined factors  Human embryonic stem cells  Keratinocyte differentiation  
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells Journal article
STEM CELLS, 2019,Volume: 37,Issue: 8,Page: 1030-1041
Authors:  Carlos Godoy‐Parejo;  Chunhao Deng;  Weiwei Liu;  Guokai Chen
Favorite  |  View/Download:11/0  |  Submit date:2020/05/21
Hesc  Cell Survival  Cell Adhesion  Focal Adhesion  Niche  Individualization  Insulin  Integrin  Caspase  Igf  Akt  
Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Journal article
STEM CELL REPORTS, 2019,Volume: 13,Issue: 2,Page: 338-351
Authors:  Chengcheng Song;  Faxiang Xu;  Zhili Ren;  Yumeng Zhang;  Ya Meng;  Yiqi Yang;  Shreyas Lingadahalli;  Edwin Cheung;  Gang Li;  Weiwei Liu;  Jianbo Wan;  Yang Zhao;  Guokai Chen
Favorite  |  View/Download:15/0  |  Submit date:2020/04/22
Hescs  Pyruvate  Bmp4  Glycolysis  Tca Cycle  Ampk  Wnt  Metabolism  Mesoderm  Differentiation  
Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells Journal article
Stem Cell Reports, 2018,Volume: 11,Issue: 6,Page: 1347-1356
Authors:  Meng Y.;  Ren Z.;  Xu F.;  Zhou X.;  Song C.;  Wang V.Y.-F.;  Liu W.;  Lu L.;  Thomson J.A.;  Chen G.
Favorite  |  View/Download:13/0  |  Submit date:2019/01/15
cell differentiation  cell survival  human pluripotent stem cell  kinase inhibitor  nicotinamide  
Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease Journal article
ORPHANET JOURNAL OF RARE DISEASES, 2018,Volume: 13
Authors:  Vu, Mylinh;  Li, Rong;  Baskfield, Amanda;  Lu, Billy;  Farkhondeh, Atena;  Gorshkov, Kirill;  Motabar, Omid;  Beers, Jeanette;  Chen, Guokai;  Zou, Jizhong;  Espejo-Mojica, Angela J.;  Rodriguez-Lopez, Alexander;  Almeciga-Diaz, Carlos J.;  Barrera, Luis A.;  Jiang, Xuntian;  Ory, Daniel S.;  Marugan, Juan J.;  Zheng, Wei
Favorite  |  View/Download:53/0  |  Submit date:2018/10/30
Tay-sachs Disease  Induced Pluripotent Stem Cells  Neural Stem Cells  Cyclodextrin  Hp Beta Cd  Delta-tocopherol  Enzyme Replacement Therapy  Hexosaminidase a  Gm2 Gangliosidosis  High Throughput Screening  Drug Discovery  
Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway Journal article
Oncotarget, 2018,Volume: 9,Issue: 62,Page: 31958-31970
Authors:  Nana Ai;  Cheong-Meng Chong.;  Weiting Chen;  Zhe Hu;  Huanxing Su;  Guokai Chen;  Queenie Wing Lei Wong;  Wei Ge
Favorite  |  View/Download:14/0  |  Submit date:2018/12/11
Angiogenesis  Enos  Huvec  Mapk  Ponatinib  
Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism Journal article
STEM CELL RESEARCH, 2018,Volume: 27,Page: 42-45
Authors:  Luo, Yumei;  Zhu, Detu;  Xu, Xiangye;  Ge, Lingxia;  Sun, Xiaofang;  Chen, Guokai;  Chen, Yaoyong
Favorite  |  View/Download:17/0  |  Submit date:2018/10/30
Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model Journal article
Cell Death Discovery, 2018,Volume: 4,Issue: 89
Authors:  Li Yan;  Bin Jiang;  Yuyu Niu;  Hongxuan Wang;  Enqin Li;  Yaping Yan;  Huiyan Sun;  Yanchao Duan;  Shaohui Chang;  Guokai Chen;  Weizhi Ji;  Ren-He Xu;  Wei Si
Favorite  |  View/Download:19/0  |  Submit date:2019/01/09
Identification of Novel Targets for Lung Cancer Therapy Using an Induced Pluripotent Stem Cell Model Journal article
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2018,Volume: 15,Page: S127-S128
Authors:  Shukla, V;  Rao, M;  Zhang, HE;  Beers, J;  Wangsa, D;  Wangsa, D;  Buishand, FO;  Wang, YH;  Yu, ZY;  Stevenson, H;  Reardon, E;  McLoughlin, KC;  Kaufman, A;  Payabyab, E;  Hong, JA;  Zhang, M;  Davis, SR;  Edelman, DC;  Chen, G;  Miettinen, M;  Restifo, N;  Ried, T;  Meltzer, PS;  Schrump, DS
Favorite  |  View/Download:4/0  |  Submit date:2019/01/09
The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 5,Page: 485-496
Authors:  Liu, Weiwei;  Ren, Zhili;  Lu, Kai;  Song, Chengcheng;  Cheung, Edwin Chong Wing;  Zhou, Zhou;  Chen, Guokai
Favorite  |  View/Download:18/0  |  Submit date:2018/10/30
Human Pluripotent Stem Cells  Acidosis  Glycolysis  Cell Death  Differentiation