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Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration Journal article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018,Volume: 38,Issue: 9,Page: 2103-2116
Authors:  Wang, Li;  Wang, Yuan;  Zhang, Chao;  Li, Jingjing;  Meng, Yuan;  Dou, Man;  Noguchi, Constance Tom;  Di, Lijun
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Adipose Tissue  Gsk3  Inflammation  Macrophages  Obesity  
GSK3-activated STAT5 regulates expression of SFRPs to modulate adipogenesis Journal article
FASEB JOURNAL, 2018,Volume: 32,Issue: 9,Page: 4714-4726
Authors:  Wang, Li;  Wang, Yuan;  Meng, Yuan;  Zhang, Chao;  Di, Lijun
Favorite  |  View/Download:192/0  |  Submit date:2018/10/30
Adipocyte Differentiation  Gsk3  Wnt Pathway  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Alzheimer's disease  tetramethylpyrazine derivative  NMDA receptor  neuroprotection  oxidative stress  GSK3 beta  
Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 11,Page: 1512-1520
Authors:  Jiang, Xiao-Ming;  Xu, Yu-Lian;  Huang, Mu-Yang;  Zhang, Le-Le;  Su, Min-Xia;  Chen, Xiuping;  Lu, Jin-Jian
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Non-small Cell Lung Cancer  Egfr  Osimertinib  Pd-l1  Ubiquitin-proteasome System  Mg-132  Bortezomib  Gsk3 Beta  Licl  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway Journal article
Cellular and Molecular Neurobiology, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu J.;  Zheng J.;  Lin J.;  Jin L.;  Yu R.;  Mak S.;  Hu S.;  Sun H.;  Wu X.;  Zhang Z.;  Lee M.;  Tsim W.;  Su W.;  Zhou W.;  Cui W.;  Han Y.;  Wang Q.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
ERK  GSK3β  H2O2  Indirubin-3-oxime  PI3-K  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui;  Mak, Shinghung;  Hu, Shengquan;  Sun, Hongya;  Wu, Xiang;  Zhang, Zaijun;  Lee, Mingyuen;  Tsim, Wahkeung;  Su, Wei;  Zhou, Wenhua;  Cui, Wei;  Han, Yifan;  Wang, Qinwen
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Indirubin-3-oxime  H2O2  GSK3 beta  PI3-K  ERK  
Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NeuroMolecular Medicine, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Hu S.;  Wang L.;  Mak S.;  Zhang Z.;  Xu D.;  Li H.;  Li Y.;  Hu Y.;  Lee S.M.Y.;  Wang Y.;  Han Y.
Favorite  |  View/Download:2/0  |  Submit date:2018/11/06
Danshensu/tetramethylpyrazine derivative  GSK3β  MEF2D  MPP+  Neuroprotection  Parkinson’s disease  
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β Journal article
Journal of Molecular Neuroscience, 2015,Volume: 57,Issue: 4,Page: 561
Authors:  Hu S.;  Cui W.;  Zhang Z.;  Mak S.;  Xu D.;  Li G.;  Hu Y.;  Wang Y.;  Lee M.;  Tsim K.W.;  Han Y.
Favorite  |  View/Download:2/0  |  Submit date:2018/10/30
6OHDA  GSK3β  Indirubin-3-oxime  MEF2D  Neuroprotection  Parkinson’s disease  
Wnt/β-catenin mediates AICAR effect in increasing GATA3 expression and inhibiting adipogenesis Journal article
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2015,Volume: 290,Issue: 32,Page: 19458 –19468
Authors:  Li Wang;  Li-jun Di
Favorite  |  View/Download:3/0  |  Submit date:2019/01/24
Adipogenesis  Ctbp  Wnt Pathway,  Glycogen Synthase Kinase 3 (Gsk3)  Gata3  Amp-activated Kinase (Ampk)  Β-catenin  Gata Transcription Factor