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Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3 Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 834,Page: 176-187
Authors:  Liu, Jing-Xin;  Shen, Sheng-Nan;  Tong, Qiang;  Wang, Yi-Tao;  Lin, Li-Gen
Favorite  |  View/Download:24/0  |  Submit date:2018/10/30
Honokiol  Oxidative Stress  Liver  Sirt3  Mitochondria  Fragmentation  
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 830,Page: 17-25
Authors:  Zhang, Le-Le;  Feng, Zhe-Ling;  Su, Min-Xia;  Jiang, Xiao-Ming;  Chen, Xiuping;  Wang, Yitao;  Li, Ao;  Lin, Li-Gen;  Lu, Jin-Jian
View  |  Adobe PDF(3226Kb)  |  Favorite  |  View/Download:121/15  |  Submit date:2018/10/30
Nagilactone e  Non-small Cell Lung Cancer  Cyclin B1  Cell Cycle  Apoptosis  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
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Cardioprotection  Anti-oxidative stress  Anti-apoptosis  Autophagy regulation  Zebrafish cardiotoxicity  H9c2 cardiomyocytes  
Ferulic acid relaxed rat aortic, small mesenteric and coronary arteries by blocking voltage-gated calcium channel and calcium desensitization via dephosphorylation of ERK1/2 and MYPT1 Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 815,Page: 26-32
Authors:  Zhou, Zhong-Yan;  Xu, Jia-Qi;  Zhao, Wai-Rong;  Chen, Xin-Lin;  Jin, Yu;  Tang, Nuo;  Tang, Jing-Yi
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Ferulic acid  Vasorelaxation  Calcium sensitization  Calcium channel  Endothelium  
Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 815,Page: 80-87
Authors:  Yang, Zheng;  Hu, Xiaohui;  Zhang, Shaolin;  Zhang, Wen;  Tam, Kin Yip
Favorite  |  View/Download:8/0  |  Submit date:2018/10/30
Synergism  Dichloroacetophenone  Dichloroacetate  Egfr  Apoptosis  Acquired Resistance  
Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 801,Page: 46-53
Authors:  Wu, Lehao;  Fan, Yunpeng;  Fan, Chao;  Yu, Yang;  Sun, Lei;  Jin, Yu;  Zhang, Yan;  Ye, Richard D.
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Licocoumarone  Glycyrrhiza uralensis  NF-kappa B  MAPKs  STAT3  
Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine Journal article
European Journal of Pharmacology, 2016,Volume: 791,Page: 544-551
Authors:  Tang P.C.T.;  Yang C.;  Li R.W.-S.;  Lee S.M.-Y.;  Hoi M.P.-M.;  Chan S.-W.;  Kwan Y.-W.;  Tse C.-M.;  Leung G.P.-H.
Favorite  |  View/Download:5/0  |  Submit date:2018/11/06
Cancer  Cardiovascular disease  Equilibrative nucleoside transporters  Inhibitor  
Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs Journal article
European Journal of Pharmacology, 2016,Volume: 789,Page: 344-353
Authors:  Li J.;  Peng Y.;  Li S.;  Sun Y.;  Chan J.Y.-W.;  Cui G.;  Wang D.;  Zhou G.-C.;  Lee S.M.-Y.
Favorite  |  View/Download:1/0  |  Submit date:2018/11/06
Andrographolide  Angiogenesis  Zebrafish  
Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines Journal article
European Journal of Pharmacology, 2016,Volume: 789,Page: 458-467
Authors:  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Dichloroacetate  Drug Combination  Epidermal Growth Factor Receptor  Erlotinib  Gefitinib  Pyruvate Dehydrogenase Kinase