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Oral Delivery of Puerarin Nanocrystals To Improve Brain Accumulation and Anti-Parkinsonian Efficacy Journal article
MOLECULAR PHARMACEUTICS, 2019,Volume: 16,Issue: 4,Page: 1444-1455
Authors:  Sha Xiong;  Wei Liu;  Dongli Li;  Xiaojia Chen;  Fang Liu;  Dongsheng Yuan;  Huafeng Pan;  Qi Wang;  Shuhuan Fang;  Tongkai Chen
Favorite | View/Download:12/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2020/01/06
Parkinson’s Disease  Brain Accumulation  Nanocrystals  Oral Delivery  Puerarin  
Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines Journal article
Advanced Drug Delivery Reviews, 2019,Volume: 143,Page: 177-205
Authors:  Tongkai Chen;  Bing He;  Jingsong Tao;  Yuan He;  Hailiang Deng;  Xueqing Wang;  Ying Zheng
Favorite | View/Download:13/0 | TC[WOS]:10 TC[Scopus]:0 | Submit date:2020/04/08
Förster Resonance Energy Transfer (Fret)  Nanomedicines  Integrity  Biofate  Micelles  Polymeric Nanoparticles  Lipid-based Nanoparticles  
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Feng, Yu;  Hoi, Maggie P. M.;  Ma, Dan;  Zhao, Chao;  Zheng, Ying;  Lee, Simon M. Y.
Favorite | View/Download:39/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/10/30
Bhdpc  Neuroinflammation  Microglia  Nf-kappa b  Creb  Pka  
Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation Journal article
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Zhang, Chao;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  He, Chengwei;  Zheng, Ying;  Lee, Simon Ming-Yuen
Favorite | View/Download:43/0 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/10/30
Schisantherin a  Neuroinflammation  Microglia  Nrf2  Nf-kappa b  
Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier Journal article
PHARMACOLOGICAL RESEARCH, 2017,Volume: 125,Page: 246-257
Authors:  Li, Ye;  Chen, Tongkai;  Miao, Xiaoqing;  Yi, Xiang;  Wang, Xueqing;  Zhao, Haitao;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite | View/Download:32/0 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/10/30
Blood Brain Barrier (Bbb)  Zebrafish  Fluorescence Dyes  Natural Products  Drug Delivery Systems  Permeability  
Pluronic P85/F68 Micelles of Baicalein Could Interfere with Mitochondria to Overcome MRP2-Mediated Efflux and Offer Improved Anti-Parkinsonian Activity Journal article
Molecular Pharmaceutics, 2017,Volume: 14,Issue: 10,Page: 3331-3342
Authors:  Tongkai Chen;  Ye Li;  Chuwen Li;  Xiang Yi;  Ruibing Wang;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite | View/Download:18/0 | TC[WOS]:8 TC[Scopus]:0 | Submit date:2018/11/06
Baicalein  Fluorescence Resonance Energy Transfer (Fret)  Micelles  Mitochondria  Multidrug Resistance-associated Protein 2 (Mrp2)  Neuroprotective Effect  
Pluronic P85/F68 Micelles of Baicalein Could Interfere with Mitochondria to Overcome MRP2-Mediated Efflux and Offer Improved Anti-Parkinsonian Activity Journal article
MOLECULAR PHARMACEUTICS, 2017,Volume: 14,Issue: 10,Page: 3331-3342
Authors:  Chen, Tongkai;  Li, Ye;  Li, Chuwen;  Yi, Xiang;  Wang, Ruibing;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite | View/Download:17/0 | TC[WOS]:8 TC[Scopus]:0 | Submit date:2018/10/30
micelles  baicalein  fluorescence resonance energy transfer (FRET)  multidrug resistance-associated protein 2 (MRP2)  mitochondria  neuroprotective effect  
Tablets of multi-unit pellet system for controlled drug delivery Journal article
JOURNAL OF CONTROLLED RELEASE, 2017,Volume: 262,Page: 222-231
Authors:  Chen, Tongkai;  Li, Jian;  Chen, Ting;  Zheng, Ying;  Sun, Changquan Calvin
Favorite | View/Download:27/0 | TC[WOS]:17 TC[Scopus]:0 | Submit date:2018/10/30
Multi-unit Pellet System (Mups)  Pellets  Coating  Cushioning Agents  Tableting Of Pellets  Drug Delivery System (Dds)  
Small-Sized mPEG PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity Journal article
ACS APPLIED MATERIALS & INTERFACES, 2017,Volume: 9,Issue: 11,Page: 9516-9527
Authors:  Chen, Tongkai;  Li, Chuwen;  Li, Ye;  Yi, Xiang;  Wang, Ruibing;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite | View/Download:39/0 | TC[WOS]:21 TC[Scopus]:0 | Submit date:2018/10/30
Brain Delivery  Cellular Uptake  Fluorescence Resonance Energy Transfer (Fret)  Mpeg-plga Nanoparticles  Oral Bioavailability  Schisantherin a  
Oral delivery of a nanocrystal formulation of schisantherin a with improved bioavailability and brain delivery for the treatment of Parkinson's disease Journal article
Molecular Pharmaceutics, 2016,Volume: 13,Issue: 11,Page: 3864-3875
Authors:  Tongkai Chen;  Chuwen Li;  Ye Li;  Xiang Yi;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite | View/Download:10/0 | TC[WOS]:18 TC[Scopus]:0 | Submit date:2018/11/06
Brain Delivery  Dissolution  Nanocrystals  Oral Bioavailability  Parkinson's Disease (Pd)