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Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
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Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
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Andrographolide  STAT3 inhibitor  Acute liver damage  Inflammation  
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 3,Page: 630-636
Authors:  Wang, Ying;  Chen, Shao-Ru;  Yang, Xiaoming;  Lee, Kuo-Hsiung;  Cheng, Yung-Chi
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C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2017,Volume: 25,Issue: 13,Page: 3512-3524
Authors:  Huang, Lie-Jun;  Chen, Shao-Ru;  Yuan, Chun-Mao;  Gu, Wei;  Guo, Bao-Jian;  Wang, Yi-Tao;  Wang, Ying;  Hao, Xiao-Jiang
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C21-steroidal pregnane steroids  Anti-inflammation  TLR  NF-kappa B  TRAF6  
C21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents Journal article
Bioorganic and Medicinal Chemistry, 2017,Volume: 25,Issue: 13,Page: 3512
Authors:  Huang L.-J.;  Chen S.-R.;  Yuan C.-M.;  Gu W.;  Guo B.-J.;  Wang Y.-T.;  Wang Y.;  Hao X.-J.
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Anti-inflammation  C21-steroidal pregnane steroids  NF-κB  TLR  TRAF6  
2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists Journal article
Bioorganic and Medicinal Chemistry, 2016,Volume: 24,Issue: 11,Page: 2530-2543
Authors:  Vergelli C.;  Schepetkin I.A.;  Ciciani G.;  Cilibrizzi A.;  Crocetti L.;  Giovannoni M.P.;  Guerrini G.;  Iacovone A.;  Kirpotina L.N.;  Khlebnikov A.I.;  Ye R.D.;  Quinn M.T.
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Agonist  Ca2+ mobilization  Formyl peptide receptor (FPR)  Neutrophil  Pyridazin-3(2H)-one  
Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino- 4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase i inhibitors and cytotoxic agents Journal article
Bioorganic and Medicinal Chemistry, 2012,Volume: 20,Issue: 14,Page: 4489-4494
Authors:  Ye D.;  Shi Q.;  Leung C.-H.;  Kim S.-W.;  Park S.-Y.;  Gullen E.A.;  Jiang Z.L.;  Zhu H.;  Morris-Natschke S.L.;  Cheng Y.-C.;  Lee K.-H.
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Camptothecin (CPT)  Conjugates  Cytotoxicity  Epipodophyllotoxin  Etoposide (VP-16)  Topoisomerase  
Structural analogs of tylophora alkaloids may not be functional analogs Journal article
Bioorganic and Medicinal Chemistry Letters, 2008,Volume: 18,Issue: 2,Page: 704-709
Authors:  Gao W.;  Chen A.P.-C.;  Leung C.-H.;  Gullen E.A.;  Furstner A.;  Shi Q.;  Wei L.;  Lee K.-H.;  Cheng Y.-C.
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Protein, DNA, and RNA synthesis  Structure-activity relationship  Tylophora alkaloids  
Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities Journal article
Bioorganic and Medicinal Chemistry, 2008,Volume: 16,Issue: 15,Page: 7141
Authors:  Liu A.-L.;  Wang H.-D.;  Lee S.M.;  Wang Y.-T.;  Du G.-H.
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Flavonoids  In vitro anti-viral activity  Neuraminidase (NA)  Structure-activity relationship (SAR)