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Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
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Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View  |  Adobe PDF(2009Kb)  |  Favorite  |  View/Download:272/37  |  Submit date:2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 3,Page: 630-636
Authors:  Wang, Ying;  Chen, Shao-Ru;  Yang, Xiaoming;  Lee, Kuo-Hsiung;  Cheng, Yung-Chi
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C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2017,Volume: 25,Issue: 13,Page: 3512-3524
Authors:  Huang, Lie-Jun;  Chen, Shao-Ru;  Yuan, Chun-Mao;  Gu, Wei;  Guo, Bao-Jian;  Wang, Yi-Tao;  Wang, Ying;  Hao, Xiao-Jiang
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C21-steroidal Pregnane Steroids  Anti-inflammation  Tlr  Nf-kappa b  Traf6  
C21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents Journal article
Bioorganic and Medicinal Chemistry, 2017,Volume: 25,Issue: 13,Page: 3512
Authors:  Huang L.-J.;  Chen S.-R.;  Yuan C.-M.;  Gu W.;  Guo B.-J.;  Wang Y.-T.;  Wang Y.;  Hao X.-J.
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Anti-inflammation  C21-steroidal Pregnane Steroids  Nf-κb  Tlr  Traf6  
2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists Journal article
Bioorganic and Medicinal Chemistry, 2016,Volume: 24,Issue: 11,Page: 2530-2543
Authors:  Vergelli C.;  Schepetkin I.A.;  Ciciani G.;  Cilibrizzi A.;  Crocetti L.;  Giovannoni M.P.;  Guerrini G.;  Iacovone A.;  Kirpotina L.N.;  Khlebnikov A.I.;  Ye R.D.;  Quinn M.T.
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Agonist  Ca2+ mobilization  Formyl peptide receptor (FPR)  Neutrophil  Pyridazin-3(2H)-one  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Bioorganic and Medicinal Chemistry Letters, 2014,Volume: 24,Issue: 21,Page: 4963-4968
Authors:  Zhang S.-L.;  Yao H.;  Wang C.;  Tam K.Y.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/18
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Tricyclic thiazoles are a new class of angiogenesis inhibitors Journal article
Bioorganic and Medicinal Chemistry Letters, 2013,Volume: 23,Issue: 9,Page: 2733-2737
Authors:  Bhat S.;  Shim J.S.;  Liu J.O.
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Angiogenesis  Endothelial cells  Tricyclic thiazoles  
Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino- 4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase i inhibitors and cytotoxic agents Journal article
Bioorganic and Medicinal Chemistry, 2012,Volume: 20,Issue: 14,Page: 4489-4494
Authors:  Ye D.;  Shi Q.;  Leung C.-H.;  Kim S.-W.;  Park S.-Y.;  Gullen E.A.;  Jiang Z.L.;  Zhu H.;  Morris-Natschke S.L.;  Cheng Y.-C.;  Lee K.-H.
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Camptothecin (CPT)  Conjugates  Cytotoxicity  Epipodophyllotoxin  Etoposide (VP-16)  Topoisomerase  
Identification and evaluation of apoptotic compounds from Garcinia oligantha Journal article
Bioorganic and Medicinal Chemistry Letters, 2012,Volume: 22,Issue: 6,Page: 2350-2353
Authors:  Gao X.-M.;  Yu T.;  Cui M.-Z.;  Pu J.-X.;  Du X.;  Han Q.-B.;  Hu Q.-F.;  Liu T.-C.;  Luo K.Q.;  Xu H.-X.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Anticancer Drug  Apoptosis  Caspase-3  Garcinia Oligantha  Xanthone