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Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model Conference paper
Frontiers in Biomedical Engineering and Biotechnology, Beijing, China, 2014-9-25-28
Authors:  Chenyin W.;  Avdeef A.;  Wen Z.;  Tam K.Y.
Favorite | View/Download:18/0 | TC[WOS]:2 TC[Scopus]:2 | Submit date:2018/12/18
Caco-2  Fluoroquinolones  Fraction Absorbed  Human Intestine  Permeability  
Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties Journal article
European Journal of Pharmaceutical Sciences, 2012,Volume: 47,Issue: 1,Page: 21-27
Authors:  Volgyi G.;  Vizseralek G.;  Takacs-Novak K.;  Avdeef A.;  Tam K.Y.
Favorite | View/Download:7/0 | TC[WOS]:24 TC[Scopus]:24 | Submit date:2018/12/18
Antimicrobial Activity  Fluoroquinolones  Mic  Pampa  Protonation Microconstants  True Partition Coefficients  
How well can the caco-2/madin-darby canine kidney models predict effective human jejunal permeability? Journal article
Journal of Medicinal Chemistry, 2010,Volume: 53,Issue: 9,Page: 3566-3584
Authors:  Avdeef A.;  Tam K.Y.
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The permeation of amphoteric drugs through artificial membranes - An in combo absorption model based on paracellular and transmembrane permeability Journal article
Journal of Medicinal Chemistry, 2010,Volume: 53,Issue: 1,Page: 392-401
Authors:  Tam K.Y.;  Avdeef A.;  Tsinman O.;  Sun N.
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PH-metric logP 11. pK(a) determination of water-insoluble drugs in organic solvent-water mixtures Journal article
Journal of Pharmaceutical and Biomedical Analysis, 1999,Volume: 20,Issue: 4,Page: 631-641
Authors:  Avdeef A.;  Box K.J.;  Comer J.E.A.;  Gilges M.;  Hadley M.;  Hibbert C.;  Patterson W.;  Tam K.Y.
Favorite | View/Download:10/0 | TC[WOS]:186 TC[Scopus]:191 | Submit date:2018/12/18
1,4-dioxane  Acetonitrile  Acid Dissociation Constants  Dimethylformamide  Dimethylsulfoxide  Ethanol  Ethylene Glycol  Methanol  Ph-metric Titration  Pk(a)  Tetrahydrofuran  
pH-Metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs Journal article
Pharmaceutical Research, 1998,Volume: 15,Issue: 2,Page: 209-215
Authors:  Avdeef A.;  Box K.J.;  Comer J.E.A.;  Hibbert C.;  Tam K.Y.
Favorite | View/Download:7/0 | TC[WOS]:302 TC[Scopus]:320 | Submit date:2018/12/18
Drug-lipid Membrane Interaction  Ionizable Drug  Liposome  Partition Coefficient