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Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 10,Page: 1279-1291
Authors:  Lei Fan;  Xiao-xia Qiu;  Zhi-yuan Zhu;  Jian-lu Lv;  Jian Lu;  Fei Mao;  Jin Zhu;  Jia-ying Wang;  Xiao-wei Guan;  Jing Chen;  Jin Ren;  Ji-ming Ye;  Yong-hua Zhao;  Jian Li;  Xu Shen
Favorite  |  View/Download:12/0  |  Submit date:2020/04/14
App/ps1 Transgenic Mice  Alzheimer’s Disease  Autophagy  Inflammation  Nitazoxanide  
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite  |  View/Download:5/0  |  Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Main active constituent identification in Guanxinjing capsule, a traditional Chinese medicine, for the treatment of coronary heart disease complicated with depression Journal article
ACTA PHARMACOLOGICA SINICA, 2018,Volume: 39,Issue: 6,Page: 975-987
Authors:  Zhang, Yan-qiong;  Guo, Qiu-yan;  Li, Qiu-yue;  Ren, Wei-qiong;  Tang, Shi-huan;  Wang, Song-song;  Liang, Ri-xin;  Li, De-feng;  Zhang, Yi;  Xu, Hai-yu;  Yang, Hong-jun
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traditional Chinese medicine  Guanxinjing capsule  coronary heart disease  depression  integrative pharmacology  in silico ADME prediction  target prediction  network analysis  
Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 11,Page: 1512-1520
Authors:  Jiang, Xiao-Ming;  Xu, Yu-Lian;  Huang, Mu-Yang;  Zhang, Le-Le;  Su, Min-Xia;  Chen, Xiuping;  Lu, Jin-Jian
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Non-small Cell Lung Cancer  Egfr  Osimertinib  Pd-l1  Ubiquitin-proteasome System  Mg-132  Bortezomib  Gsk3 Beta  Licl  
Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of alpha-tocopheryl succinate-based polyphosphoester copolymers Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 6,Page: 859-873
Authors:  Chen, Feng-qian;  Zhang, Jin-ming;  Fang, Xie-fan;  Yu, Hua;  Liu, Yu-ling;  Li, Hui;  Wang, Yi-tao;  Chen, Mei-wan
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
Ovarian Carcinoma  Paclitaxel  Multidrug Resistance  Nanomedicines  D-alpha-tocopheryl Succinate  Redox-responsive Micelles  P-gp  Apoptosis  Cell Cycle Arrest  A2780/ptx Cells  
Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of α-Tocopheryl succinate-based polyphosphoester copolymers Journal article
Acta Pharmacologica Sinica, 2017,Volume: 38,Issue: 6,Page: 859
Authors:  Chen F.-Q.;  Zhang J.-M.;  Fang X.-F.;  Yu H.;  Liu Y.-L.;  Li H.;  Wang Y.-T.;  Chen M.-W.
Favorite  |  View/Download:16/0  |  Submit date:2018/10/31
A2780/ptx Cells  Apoptosis  Cell Cycle Arrest  d-?-tocopheryl Succinate  Multidrug Resistance  Nanomedicines  Ovarian Carcinoma  P-gp  Paclitaxel  Redox-responsive Micelles  
Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells Journal article
Acta Pharmacologica Sinica, 2015,Volume: 36,Issue: 12,Page: 1503
Authors:  Li T.;  Xu X.-H.;  Tang Z.-H.;  Wang Y.-F.;  Leung C.-H.;  Ma D.-L.;  Chen X.-P.;  Wang Y.-T.;  Chen Y.;  Lu J.-J.
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Apoptosis  Autophagy  Erk  Baf  Bel-7402 Cells  Chloroquine  Human Hepatocellular Carcinoma  Jnk  Platycodin d  Sp600125  U0126  
Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway Journal article
Acta Pharmacologica Sinica, 2014,Volume: 35,Issue: 5,Page: 653-663
Authors:  Zhou J.-X.;  Liao D.;  Zhang S.;  Cheng N.;  He H.-Q.;  Ye R.D.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/07
calcium flux  chemerin  CMKLR1  endocytosis  ERK phosphorylation  GPCR  receptor internalization  receptor trafficking  
Autophagy in ageing and ageing-associated diseases Journal article
Acta Pharmacologica Sinica, 2013,Volume: 34,Issue: 5,Page: 605-611
Authors:  He, Li-qiang;  Lu, Jia-hong;  Yue, Zhen-yu
Favorite  |  View/Download:6/0  |  Submit date:2019/01/19
Autophagy  Neurodegenerative Diseases  Sirtuin 1  P53  Rapamycin  Resveratrol  Spermidine  Ageing  Ageing-associated Diseases  Cancer  
Ganoderiol A-enriched extract suppresses migration and adhesion via inhibiting FAK-SRC-paxillin cascade pathway in MDA-MB-231 cells Journal article
ACTA PHARMACOLOGICA SINICA, 2013,Volume: 34,Page: 32-32
Authors:  Wu, GS;  Song, YL;  Yin, ZQ;  Guo, JJ;  Wang, SP;  Zhao, WW;  Chen, XP;  Zhang, QW;  Lu, JJ;  Wang, YT
Favorite  |  View/Download:7/0  |  Submit date:2020/03/30