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N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF Journal article
MOLECULAR NEUROBIOLOGY, 2018,Volume: 55,Issue: 3,Page: 2258-2267
Authors:  Luo, Dan;  Zhao, Jia;  Cheng, Yuanyuan;  Lee, Simon Ming-Yuen;  Rong, Jianhui
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Parkinson's disease  Neuroprotection  N-propargyl caffeamide (PACA)  NGF/TrkApathway  PI3K/Akt  ERK1/2  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
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Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways Journal article
REDOX BIOLOGY, 2017,Volume: 11
Authors:  Zhang, Chao;  Li, Chuwen;  Chen, Shenghui;  Li, Zhiping;  Jia, Xuejing;  Wang, Kai;  Bao, Jiaolin;  Liang, Yeer;  Wang, Xiaotong;  Chen, Meiwan;  Li, Peng;  Su, Huanxing;  Wan, Jian-Bo;  Lee, Simon Ming Yuen;  Liu, Kechun;  He, Chengwei
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Berberine  Hormesis  Neuroprotection  Pc12 Cells  Zebrafish  
Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction Journal article
CNS Neuroscience and Therapeutics, 2014,Volume: 20,Issue: 3,Page: 244-252
Authors:  Cui W.;  Zhang Z.-J.;  Hu S.-Q.;  Mak S.-H.;  Xu D.-P.;  Choi C.-L.;  Wang Y.-Q.;  Tsim W.-K.;  Lee M.-Y.;  Rong J.-H.;  Han Y.-F.
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Cancer  Neuroprotection  Nitric Oxide  Nitric Oxide Synthase  Receptor Tyrosine Kinase  Sunitinib  
Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice Journal article
Pharmacology Biochemistry and Behavior, 2014,Volume: 122,Page: 191-202
Authors:  Zhang Z.;  Lai D.;  Wang L.;  Yu P.;  Zhu L.;  Guo B.;  Xu L.;  Zhou L.;  Sun Y.;  Lee S.M.Y.;  Wang Y.
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Andrographolide-lipoic Acid Conjugate  Neuroprotection  Nf-κb P65  Parkinson's Disease  
The anti-cancer agent SU4312 unexpectedly protects against MPP+- induced neurotoxicity via selective and direct inhibition of neuronal NOS Journal article
British Journal of Pharmacology, 2013,Volume: 168,Issue: 5,Page: 1201
Authors:  Cui W.;  Zhang Z.;  Li W.;  Hu S.;  Mak S.;  Zhang H.;  Han R.;  Yuan S.;  Li S.;  Sa F.;  Xu D.;  Lin Z.;  Zuo Z.;  Rong J.;  Ma E.D.-L.;  Choi T.C.;  Lee S.M.;  Han Y.
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Angiogenesis  Mpp++++  Neuronal Nos  Neuroprotection  Parkinson's Disease  Su4312  
Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish Journal article
International Journal of Molecular Medicine, 2011,Volume: 27,Issue: 2,Page: 195
Authors:  Zhang Z.J.;  Cheang L.C.V.;  Wang M.W.;  Lee S.M.-Y.
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Neuroprotection  Parkinson's Disease  Quercetin  Zebrafish