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Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite  |  View/Download:8/0  |  Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors Journal article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019,Volume: 20,Issue: 18
Authors:  Leung, CH;  Zhang, JT;  Yang, GJ;  Liu, H;  Han, QB;  Ma, DL
Favorite  |  View/Download:5/0  |  Submit date:2020/03/23
Virtual Screening  Keap1-nrf2  Protein-protein Interaction  Inhibitors  Oxidative Stress  
Small Molecule Pin1 Inhibitor Blocking NF-B Signaling in Prostate Cancer Cells Journal article
CHEMISTRY-AN ASIAN JOURNAL, 2018,Volume: 13,Issue: 3,Page: 275-279
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Yang, Guanjun;  Wu, Chun;  Huang, Jie-Min;  Li, Guodong;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:27/0  |  Submit date:2018/10/30
Enzymes  Natural Products  Pin1  Protein-protein Interactions  Virtual Screening  
Recent Advances in the Discovery and Development of Protein-Protein Interaction Modulators by Virtual Screening Book
2015
Authors:  Ma D.-L.;  Liu L.-J.;  Lin S.;  Wang M.;  Chan D.S.-H.;  Leung C.-H.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
Computer-aided drug discovery  Drug development  Molecular docking  Protein-protein interactions  Virtual screening  
Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening Journal article
Methods, 2015,Volume: 71,Issue: C,Page: 38-43
Authors:  Leung K.-H.;  Liu L.-J.;  Lin S.;  Lu L.;  Zhong H.-J.;  Susanti D.;  Rao W.;  Wang M.;  Che W.I.;  Chan D.S.H.;  Leung C.-H.;  Chan P.W.H.;  Ma D.-L.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
Pharmacophore  Protein-protein interaction  STAT3  Virtual screening  
In silico identification of natural product inhibitors of JAK2 Journal article
Methods, 2015,Volume: 71,Issue: C,Page: 21-25
Authors:  Zhong H.-J.;  Lin S.;  Tam I.L.;  Lu L.;  Chan D.S.-H.;  Ma D.-L.;  Leung C.-H.
Favorite  |  View/Download:3/0  |  Submit date:2018/11/06
6-Chloroemodic acid  Emodic acid  JAK2  Natural product  Virtual screening  
Pharmacophore modeling for the identification of small-molecule inhibitors of TACE Journal article
Methods, 2015,Volume: 71,Issue: C,Page: 92-97
Authors:  Liu L.-J.;  Leung K.-H.;  Lin S.;  Chan D.S.-H.;  Susanti D.;  Rao W.;  Chan P.W.H.;  Ma D.-L.;  Leung C.-H.
Favorite  |  View/Download:5/0  |  Submit date:2018/11/06
Inhibitor  Pharmacophore  TACE  Tumor necrosis factor  Virtual screening  
In silico screening of quadruplex-binding ligands Journal article
Methods, 2012,Volume: 57,Issue: 1,Page: 106
Authors:  Ma D.-L.;  Ma V.P.Y.;  Chan D.S.H.;  Leung K.-H.;  Zhong H.-J.;  Leung C.-H.
Favorite  |  View/Download:5/0  |  Submit date:2018/10/30
G-quadruplex  High-throughput  In silico  Ligands  Molecular docking  Virtual screening  
Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening Journal article
Biochimie, 2012,Volume: 94,Issue: 11,Page: 2457
Authors:  Zhong H.-J.;  Pui-Yan Ma V.;  Cheng Z.;  Shiu-Hin Chan D.;  He H.-Z.;  Leung K.-H.;  Ma D.-L.;  Leung C.-H.
Favorite  |  View/Download:4/0  |  Submit date:2018/10/30
Drug discovery  Natural product  NEDD8-activating enzyme  Ubiquitin-like protein  Virtual screening  
Structure-Based Discovery of Natural Product-Like TNF-alpha Inhibitors Journal article
Angew Chem Int Ed, 2010,Volume: 49,Issue: 16,Page: 2860-2864
Authors:  Chan DSH;  Lee HM;  Yang F;  Che CM;  Wong CCL;  Abagyan R;  Leung CH;  Ma DL
Favorite  |  View/Download:6/0  |  Submit date:2018/11/29
Inhibitors  Tumor Necrosis Factor  Virtual Screening  Natural Products  Drug Discovery