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Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice Journal article
Journal of Cellular Physiology, 2019,Volume: 234,Issue: 1,Page: 595-605
Authors:  Wang Q.;  Tan Q.;  Xu W.;  Kuang L.;  Zhang B.;  Wang Z.;  Ni Z.;  Su N.;  Jin M.;  Li C.;  Jiang W.;  Huang J.;  Li F.;  Zhu Y.;  Chen H.;  Du X.;  Chen D.;  Deng C.;  Qi H.;  Xie Y.;  Chen L.
Favorite  |  View/Download:19/0  |  Submit date:2018/12/13
Activing Receptor-like Kinases 5 (Alk5)  Matrix Degradation  Meniscal Degeneration  Transforming Growth Factor-β (Tgf-β) Signaling  
Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model Journal article
Molecular Therapy - Nucleic Acids, 2018,Volume: 13,Page: 291-302
Authors:  Luo F.;  Xie Y.;  Wang Z.;  Huang J.;  Tan Q.;  Sun X.;  Li F.;  Li C.;  Liu M.;  Zhang D.;  Xu M.;  Su N.;  Ni Z.;  Jiang W.;  Chang J.;  Chen H.;  Chen S.;  Xu X.;  Deng C.;  Wang Z.;  Du X.;  Chen L.
Favorite  |  View/Download:16/0  |  Submit date:2018/12/13
Adeno-associated Virus  Apert Syndrome  Craniosynostosis  Fgfr2  Molecular Therapy  Rnai  
A novel FGFR1-binding peptide attenuates the degeneration ofarticular cartilage in adult mice Journal article
Osteoarthritis and Cartilage, 2018,Volume: 26,Issue: 12,Page: 1733-1743
Authors:  Q. Tan;  B. Chen;  Q. Wang;  W.Xu;  Y.Wang;  Z. Lin;  F.Luo;  S. Huang;  Y.Zhu;  N. Su;  M. Jin;  C.Li;  L. Kuang;  H.Qi;  Z.Ni;  Z. Wang;  X. Luo;  W. Jiang;  H. Chen;  S. Chen;  F.Li;  B. Zhang;  J. Huang;  R. Zhang;  K. Jin;  X.Xu;  C. Deng;  X.Du;  Y. Xie;  L. Chen
Favorite  |  View/Download:17/0  |  Submit date:2018/12/17
Fgfr1  Peptide  Osteoarthritis  Mice  
A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice Journal article
Osteoarthritis and Cartilage, 2018,Volume: 26,Issue: 12,Page: 1733-1743
Authors:  Tan Q.;  Chen B.;  Wang Q.;  Xu W.;  Wang Y.;  Lin Z.;  Luo F.;  Huang S.;  Zhu Y.;  Su N.;  Jin M.;  Li C.;  Kuang L.;  Qi H.;  Ni Z.;  Wang Z.;  Luo X.;  Jiang W.;  Chen H.;  Chen S.;  Li F.;  Zhang B.;  Huang J.;  Zhang R.;  Jin K.;  Xu X.;  Deng C.;  Du X.;  Xie Y.;  Chen L.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/17
FGFR1  Mice  Osteoarthritis  Peptide  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite  |  View/Download:23/0  |  Submit date:2018/12/17
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite  |  View/Download:12/0  |  Submit date:2018/12/17
Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation Journal article
JOURNAL OF BONE AND MINERAL RESEARCH, 2017,Volume: 32,Issue: 11,Page: 2194-2206
Authors:  Xu, Wei;  Luo, Fengtao;  Wang, Quan;  Tan, Qiaoyan;  Huang, Junlan;  Zhou, Siru;  Wang, Zuqiang;  Sun, Xianding;  Kuang, Liang;  Jin, Min;  Su, Nan;  Jiang, Wanling;  Chen, Liang;  Qi, Huabing;  Zhu, Ying;  Chen, Bo;  Chen, Hangang;  Chen, Shuai;  Gao, Yu;  Xu, Xiaoling;  Deng, Chuxia;  Chen, Lin;  Xie, Yangli;  Du, Xiaolan
Favorite  |  View/Download:16/0  |  Submit date:2018/10/30
Bone Marrow Ablation  Fgfr2  Bone Formation  Wnt/beta-catenin  
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion Journal article
CELL REPORTS, 2017,Volume: 18,Issue: 13,Page: 3155-3166
Authors:  Chen, Qiang;  Hao, Wenhui;  Xiao, Cuiying;  Wang, Ruihong;  Xu, Xiaoling;  Lu, Huiyan;  Chen, Weiping;  Deng, Chu-Xia
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin Journal article
Oncotarget, 2016,Volume: 7,Issue: 51,Page: 84439-84452
Authors:  Chisholm C.L.;  Wang H.;  Wong A.H.-H.;  Vazquez-Ortiz G.;  Chen W.;  Xu X.;  Deng C.-X.
Favorite  |  View/Download:5/0  |  Submit date:2018/12/13
Atp7a  Breast Cancer  Cisplatin  Copper  Resistance  Sequestering  
SIRT1 deacetylates TopBP1 and modulates intra-sphase checkpoint and DNA replication origin firing Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 10,Page: 1193-1202
Authors:  Wang R.-H.;  Lahusen T.J.;  Chen Q.;  Xu X.;  Miller Jenkins L.M.;  Leo E.;  Fu H.;  Aladjem M.;  Pommier Y.;  Appella E.;  Deng C.-X.
Favorite  |  View/Download:9/0  |  Submit date:2018/12/13
Dna Replication Fork  Genetic Stability  Intra-s-phase Checkpoint  Sirt1  Topbp1