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Statins and PPARα agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment Journal article
Toxicology and Applied Pharmacology, 2005,Volume: 208,Issue: 3,Page: 210-221
Authors:  Johnson T.E.;  Zhang X.;  Shi S.;  Umbenhauer D.R.
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Co-treatment  Myopathy  Myotoxicity  Statin PPAR  Synergy  
Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinone Journal article
Toxicology and Applied Pharmacology, 2004,Volume: 200,Issue: 3,Page: 237-250
Authors:  Johnson T.E.;  Zhang X.;  Bleicher K.B.;  Dysart G.;  Loughlin A.F.;  Schaefer W.H.;  Umbenhauer D.R.
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Apoptosis  CPK  creatine phosphokinase  F-OH  F-PP  farnesol  farnesylpyrophosphate  farnesyltransferase  FTase  geranylgeraniol  Geranylgeranylation  geranylgeranylpyrophosphate  GG-OH  GG-PP  GGTase  HMG-CoA reductase  HMGr  Myotoxicity  Myotube  Statin