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Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer Journal article
SCIENCE SIGNALING, 2018,Volume: 11,Issue: 511
Authors:  Nie, Yingjie;  He, Jiang;  Shirota, Hidekazu;  Trivett, Anna L.;  Yang, De;  Klinman, Dennis M.;  Oppenheim, Joost J.;  Chen, Xin
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Nie, Yingjie;  Yang, De;  Trivett, Anna;  Han, Zhen;  Xin, Haiyun;  Chen, Xin;  Oppenheim, Joost J.
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer Journal article
SCIENCE SIGNALING, 2017,Volume: 10,Issue: 462
Authors:  Chen, Xin;  Oppenheim, Joost J.
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity Journal article
Nature Reviews Rheumatology, 2016,Volume: 12,Issue: 11,Page: 625–626
Authors:  Xin Chen;  Joost J Oppenheim
Favorite  |  View/Download:9/0  |  Submit date:2018/11/30
Autoimmunity  Rheumatoid Arthritis  t Cells  Tumour-necrosis Factors  
Th17 cells and Tregs: unlikely allies Journal article
JOURNAL OF LEUKOCYTE BIOLOGY, 2014,Volume: 95,Issue: 5,Page: 723-731
Authors:  Xin Chen;  Joost J. Oppenheim
Favorite  |  View/Download:7/0  |  Submit date:2019/01/14
Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide Journal article
ONCOIMMUNOLOGY, 2014,Volume: 3,Issue: 4
Authors:  Xin Chen;  Lalage M Wakefield;  Joost J Oppenheim
Favorite  |  View/Download:2/0  |  Submit date:2019/01/14
Anti-tgfβ Antibody  Cyclophosphamide  Chemoimmunotherapy  
In vitro generated Th17 cells support the expansion and phenotypic stability of CD4+ Foxp3+ regulatory T cells in vivo Journal article
CYTOKINE, 2014,Volume: 65,Issue: 1,Page: 56-64
Authors:  Qiong Zhou;  Ya Hu;  O.M. Zack Howard;  Joost J. Oppenheim;  Xin Chen
Favorite  |  View/Download:5/0  |  Submit date:2019/01/14
Regulatory t Cell  Il-2  Tnf  Tnfr2  Th17  
Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide on a mouse model of breast cancer Journal article
PLOS ONE, 2014,Volume: 9,Issue: 1
Authors:  Xin Chen;  Yuan Yang;  Qiong Zhou;  Jonathan M. Weiss;  OlaMae Zack Howard;  John M. McPherson;  Lalage M. Wakefield;  Joost J. Oppenheim
Favorite  |  View/Download:3/0  |  Submit date:2019/01/14
TNFR2 Is Critical for the Stabilization of the CD4+ Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment Journal article
JOURNAL OF IMMUNOLOGY, 2013,Volume: 190,Issue: 3,Page: 1076-1084
Authors:  Xin Chen;  Xueqing Wu;  Qiong Zhou;  O.M. Zack Howard;  Mihai G. Netea;  Joost J. Oppenheim
Favorite  |  View/Download:3/0  |  Submit date:2019/01/14
Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity Journal article
FEBS LETTERS, 2011,Volume: 585,Issue: 23,Page: 3611-3618
Authors:  Xin Chen;  Joost J. Oppenheim
Favorite  |  View/Download:3/0  |  Submit date:2019/01/14
Tnf  Tnfr2  Regulatory t Cells (Tregs)  Effector t Cells (Teffs)