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BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB Journal article
Frontiers in Pharmacology, 2018,Volume: 9,Issue: JUN
Authors:  Li C.;  Chen T.;  Zhou H.;  Feng Y.;  Hoi M.P.M.;  Ma D.;  Zhao C.;  Zheng Y.;  Lee S.M.Y.
Favorite | View/Download:13/0 | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/11/06
BHDPC  CREB  Microglia  Neuroinflammation  NF-κB  PKA  
A novel ShK-like toxic peptide fromthe transcriptome of the cnidarian Palythoa caribaeorum displays neuroprotection and cardioprotection in zebrafish Journal article
Toxins, 2018,Volume: 10,Issue: 6
Authors:  Liao Q.;  Gong G.;  Siu S.W.I.;  Wong C.T.T.;  Yu H.;  Tse Y.C.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite | View/Download:18/0 | TC[WOS]:4 TC[Scopus]:6 | Submit date:2018/11/06
Animal toxins  Calcium-activated K+ ion channel  Dynamics simulation  ShK-like peptide  Voltage-gated K+ ion channel  Zoantharian  
Inhibitory effects of betulinic acid on LPS-induced neuroinflammation involve M2 microglial polarization via CaMKKβ-dependent AMPK activation Journal article
Frontiers in Molecular Neuroscience, 2018,Volume: 11
Authors:  Li C.;  Zhang C.;  Zhou H.;  Feng Y.;  Tang F.;  Hoi M.P.M.;  He C.;  Ma D.;  Zhao C.;  Lee S.M.Y.
Favorite | View/Download:13/0 | TC[WOS]:23 TC[Scopus]:24 | Submit date:2018/11/06
AMP-activated protein kinase  Betulinic acid  Calmodulin-dependent protein kinase β  Microglia polarization  Neuroinflammation  
N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson’s Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF Journal article
Molecular Neurobiology, 2018,Volume: 55,Issue: 3,Page: 2258-2267
Authors:  Luo D.;  Zhao J.;  Cheng Y.;  Lee S.M.-Y.;  Rong J.
Favorite | View/Download:6/0 | TC[WOS]:8 TC[Scopus]:13 | Submit date:2018/11/06
ERK1/2  N-propargyl caffeamide (PACA)  Neuroprotection  NGF/TrkA pathway  Parkinson’s disease  PI3K/Akt  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
Neuropharmacology, 2017,Volume: 126,Page: 12-24
Authors:  Guo B.;  Hu S.;  Zheng C.;  Wang H.;  Luo F.;  Li H.;  Cui W.;  Yang X.;  Cui G.;  Mak S.;  Choi T.C.-L.;  Ma E.D.-L.;  Wang Y.;  Lee S.M.Y.;  Zhang Z.;  Han Y.
Favorite | View/Download:16/0 | TC[WOS]:7 TC[Scopus]:11 | Submit date:2018/11/06
Monoamine oxidase-B  Myocyte enhancer factor 2D  Neuroprotection  Parkinson's disease  SU4312  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
Neuropharmacology, 2017,Volume: 126,Page: 12-24
Authors:  Guo B.;  Hu S.;  Zheng C.;  Wang H.;  Luo F.;  Li H.;  Cui W.;  Yang X.;  Cui G.;  Mak S.;  Choi T.C.-L.;  Ma E.D.-L.;  Wang Y.;  Lee S.M.Y.;  Zhang Z.;  Han Y.
Favorite | View/Download:19/0 | TC[WOS]:7 TC[Scopus]:11 | Submit date:2018/11/06
Monoamine oxidase-B  Myocyte enhancer factor 2D  Neuroprotection  Parkinson's disease  SU4312  
Genipin derivatives protect RGC-5 from sodium Nitroprusside-induced Nitrosative stress Journal article
International Journal of Molecular Sciences, 2016,Volume: 17,Issue: 1
Authors:  Wang R.;  Zhao J.;  Zhang L.;  Peng L.;  Zhang X.;  Zheng W.;  Chen H.
Favorite | View/Download:6/0 | TC[WOS]:0 TC[Scopus]:3 | Submit date:2018/12/21
Apoptosis  Genipin  Neurodegeneration  Neuroprotection  Nitric oxide synthase  NO neurotoxicity  
Chemically bonding of amantadine with gardenamide A enhances the neuroprotective effects against corticosterone-induced insults in PC12 cells Journal article
International Journal of Molecular Sciences, 2015,Volume: 16,Issue: 9,Page: 22795-22810
Authors:  Zhao J.;  Peng L.;  Zheng W.;  Wang R.;  Zhang L.;  Yang J.;  Chen H.
Favorite | View/Download:6/0 | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/12/21
Amantadine  eNOS  Gardenamide A  Neuroprotection  NMDA  nNOS  
Gardenamide a protects RGC-5 cells from H2O2-induced oxidative stress insults by activating PI3K/Akt/eNOS signaling pathway Journal article
International Journal of Molecular Sciences, 2015,Volume: 16,Issue: 9,Page: 22350-22367
Authors:  Wang R.;  Peng L.;  Zhao J.;  Zhang L.;  Guo C.;  Zheng W.;  Chen H.
Favorite | View/Download:4/0 | TC[WOS]:17 TC[Scopus]:20 | Submit date:2018/12/21
Cell apoptosis  Gardenamide A  Neuroprotection  Neurotoxicity  Oxidative stress  
IGF-1 Signaling via the PI3K/Akt Pathway Confers Neuroprotection in Human Retinal Pigment Epithelial Cells Exposed to Sodium Nitroprusside Insult Journal article
Journal of Molecular Neuroscience, 2015,Volume: 55,Issue: 4,Page: 931-940
Authors:  Wang H.;  Liao S.;  Geng R.;  Zheng Y.;  Liao R.;  Yan F.;  Thrimawithana T.;  Little P.J.;  Feng Z.-P.;  Lazarovici P.;  Zheng W.
Favorite | View/Download:7/0 | TC[WOS]:22 TC[Scopus]:24 | Submit date:2018/12/21
Akt  Apoptosis  Insulin-like growth factor-1  MAP kinase  Nitric oxide  Protection  Retinal pigment epithelium