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Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:24/0  |  Submit date:2018/10/30
Sodium Tanshinone Iia Sulfonate  Salvia Miltiorrhiza  Hemorrhagic Stroke  Atorvastatin  Rock  
Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis Journal article
Journal of Ethnopharmacology, 2016,Volume: 181,Page: 50
Authors:  Bin-Rui Yang;  Kwok-Kuen Cheung;  Xin Zhou;  Rui-Fang Xie;  Pei-Pei Cheng;  Shen Wu;  Zhong-Yan Zhou;  Jing Yi Tang;  Pui Man Hoi;  You-Hua Wang;  Simon Ming-Yuen Lee
Favorite  |  View/Download:7/0  |  Submit date:2018/10/30
Angiogenesis  Apoptosis  Myocardial Infarction  Panax Notoginseng Flower  Saponin  
Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway Journal article
Scientific Reports, 2015,Volume: 5
Authors:  Shang Li;  Yuanye Dang;  Xuelin Zhou;  Bin Huang;  Xiaohui Huang;  Zherui Zhang;  Yiu Wa Kwan;  Shun Wan Chan;  George Pak Heng Leung;  Simon Ming Yuen Lee;  Maggie Pui Man Hoi
Favorite  |  View/Download:18/0  |  Submit date:2018/11/06
Zebrafish models of cardiovascular diseases and their applications in herbal medicine research Journal article
European journal of pharmacology, 2015,Volume: 768,Page: 77-86
Authors:  Sai-Wang Seto;  Hosen Kiat;  Simon M.Y. Lee;  Alan Bensoussan;  Yu-Ting Sun;  Maggie P.M. Hoi;  Dennis Chang
Favorite  |  View/Download:7/0  |  Submit date:2019/01/22
Zebrafish  Chinese Herbal Medicine  Cardiovascular  Animal Model  Review  
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3 β pathways Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2015,Volume: 170,Page: 8-15
Authors:  Lun Qing Zhang;  Fei Sa;  Cheong Meng Chong;  Ying Wang;  Zhong Yan Zhou;  Raymond Chuen Chung Chang;  Shun Wan Chan;  Pui Man Hoi;  Simon Ming Yuen Lee
Favorite  |  View/Download:3/0  |  Submit date:2020/04/15
6-hydroxydopamine (6-ohda)  Oxidative Stress  Parkinson׳s Disease  Schisantherin a  
Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis Journal article
Biochimica et Biophysica Acta - General Subjects, 2015,Volume: 1850,Issue: 2,Page: 373-384
Authors:  Li S.;  Zhou X.L.;  Dang Y.Y.;  Kwan Y.W.;  Chan S.W.;  Leung G.P.H.;  Lee S.M.-Y.;  Hoi M.P.M.
Favorite  |  View/Download:6/0  |  Submit date:2018/11/06
Calycosin  Endothelial Cell  Flt1  Molecular Docking  Vegf Receptor Inhibitor  Zebrafish  
VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation Journal article
Toxicology and Applied Pharmacology, 2014,Volume: 280,Issue: 3,Page: 408-420
Authors:  Li S.;  Dang Y.Y.;  Oi Lam Che G.;  Kwan Y.W.;  Chan S.W.;  Leung G.P.H.;  Lee S.M.Y.;  Hoi M.P.M.
Favorite  |  View/Download:9/0  |  Submit date:2018/11/06
Cardiovascular Protective Agents  Cardiovascular Toxicity  Vascular Insufficiency  Zebrafish Model  
In vivo angiogenesis screening and mechanism of action of novel tanshinone derivatives produced by one-pot combinatorial modification of natural tanshinone mixture from Salvia miltiorrhiza Journal article
PLoS ONE, 2014,Volume: 9,Issue: 7
Authors:  Zhang Z.-R.;  Li J.-H.;  Li S.;  Liu A.-L.;  Hoi P.-M.;  Tian H.-Y.;  Ye W.-C.;  Lee S.M.-Y.;  Jiang R.-W.
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
Zebrafish as a new model for drug metabolism and high content screen of natural product Conference paper
PLANTA MEDICA, Guimaraes, PORTUGAL, AUG 31-SEP 04, 2014
Authors:  Lee, SMY;  Hoi, PM;  Yan, R;  Wang, YQ;  Han, YF;  Chu, IK
Favorite  |  View/Download:7/0  |  Submit date:2020/03/26
Drug Metabolism  Chinese Medicine  Zebrafish  Neurodegeneration  Vascular Disease  
Zebrafish as a new model for drug metabolism and high content screen of natural product Journal article
PLANTA MEDICA, 2014,Volume: 80,Issue: 16
Authors:  Lee, SMY;  Hoi, PM;  Yan, R;  Wang, YQ;  Han, YF;  Chu, IK
Favorite  |  View/Download:5/0  |  Submit date:2020/03/26
Neurodegeneration  Chinese Medicine  Zebrafish  Drug Metabolism  Vascular Disease