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Aurone derivatives as Vps34 inhibitors that modulate autophagy Journal article
ACTA PHARMACEUTICA SINICA B, 2019,Volume: 9,Issue: 3,Page: 537-544
Authors:  Guodong Li;  Joshua William Boyle;  Chung-Nga Ko;  Wu Zeng;  Vincent Kam Wai Wong;  Jian-Bo Wan;  Philip Wai Hong Chan;  Dik-Lung Ma;  Chung-Hang Leung
Favorite  |  View/Download:8/0  |  Submit date:2020/03/24
Autophagy  Natural Products  Vps34  Inhibitor  Structure-based Virtualscreening  Vesicle Trafficking  Heart Or Liver Damage  Aurone Derivative  
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite  |  View/Download:8/0  |  Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors Journal article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019,Volume: 20,Issue: 18
Authors:  Leung, CH;  Zhang, JT;  Yang, GJ;  Liu, H;  Han, QB;  Ma, DL
Favorite  |  View/Download:5/0  |  Submit date:2020/03/23
Virtual Screening  Keap1-nrf2  Protein-protein Interaction  Inhibitors  Oxidative Stress  
Chemoselective detection of alkyl halides via an iridium(III) luminescent probe Journal article
DYES AND PIGMENTS, 2018,Volume: 159,Page: 479-482
Authors:  Wu, Chun;  Liu, Jin-Biao;  Li, Guodong;  Wong, Suk-Yu;  Han, Quan-Bin;  Leung, Chung-Hang;  Ma, Dik-Lung
View  |  Adobe PDF(687Kb)  |  Favorite  |  View/Download:400/30  |  Submit date:2018/10/30
Alkyl Halides  Iridium  Chemosensor  
Pharmacological Inhibition of LSD1 for Cancer Treatment Journal article
MOLECULES, 2018,Volume: 23,Issue: 12
Authors:  Yang, Guan-Jun;  Lei, Pui-Man;  Wong, Suk-Yu;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:17/0  |  Submit date:2019/01/17
Lsd1  Demethylase  Histone  Breast Cancer  Prostate Cancer  Acute Myeloid Leukemia  Cancer Therapy  
Small Molecule Pin1 Inhibitor Blocking NF-B Signaling in Prostate Cancer Cells Journal article
CHEMISTRY-AN ASIAN JOURNAL, 2018,Volume: 13,Issue: 3,Page: 275-279
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Yang, Guanjun;  Wu, Chun;  Huang, Jie-Min;  Li, Guodong;  Ma, Dik-Lung;  Leung, Chung-Hang
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Enzymes  Natural Products  Pin1  Protein-protein Interactions  Virtual Screening  
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:21/0  |  Submit date:2018/10/30
Drug Repurposing  Mitoxantrone  Nedd8  Ubiquitin  
Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing Journal article
CHEMICAL RECORD, 2017,Volume: 17,Issue: 11,Page: 1135-1145
Authors:  Ma, Dik-Lung;  Dong, Zhen-Zhen;  Vellaisamy, Kasipandi;  Cheung, Ka-Man;  Yang, Guanjun;  Leung, Chung-Hang
View  |  Adobe PDF(1178Kb)  |  Favorite  |  View/Download:367/15  |  Submit date:2018/10/30
G-quadruplex  Enzyme  Iridium(Iii) Complex  Luminescent Enhancement  
Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction Journal article
Chemical Communications, 2016,Volume: 52,Issue: 34,Page: 5788-5791
Authors:  Zhong H.-J.;  Lee B.R.;  Boyle J.W.;  Wang W.;  Ma D.-L.;  Hong Chan P.W.;  Leung C.-H.
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Development of an Iridium(III) Complex as a G-Quadruplex Probe and Its Application for the G-Quadruplex-Based Luminescent Detection of Picomolar Insulin Journal article
Analytical Chemistry, 2016,Volume: 88,Issue: 1,Page: 981
Authors:  Wang M.;  Wang W.;  Kang T.-S.;  Leung C.-H.;  Ma D.-L.
Favorite  |  View/Download:4/0  |  Submit date:2018/10/30