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Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2017,Volume: 330,Page: 65-73
Authors:  Li, Ting;  Chen, Xin;  Dai, Xiao-Yang;  Wei, Bin;  Weng, Qin-Jie;  Chen, Xiuping;  Ouyang, De-Fang;  Yan, Ru;  Huang, Zhang-Jian;  Jiang, Hu-Lin;  Zhu, Hong;  Lu, Jin-Jian
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Everolimus  Platycodin d  Hsp90  Cdc37  Egfr  Igf1r  
Pharmacokinetic alterations of rhubarb anthraquinones in experimental colitis induced by dextran sulfate sodium in the rat Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2017,Volume: 198,Page: 600-607
Authors:  Wu, Wen-Jin;  Yan, Ru;  Li, Ting;  Li, Ya-Ping;  Zhou, Rui-Na;  Wang, Yi-Tao
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
Special section on drug metabolism and the microbiome the presystemic interplay between gut microbiota and orally administered calycosin-7-O-β-D-Glucoside Journal article
Drug Metabolism and Disposition, 2015,Volume: 43,Issue: 10,Page: 1601-1611
Authors:  Ruan J.-Q.;  Li S.;  Li Y.-P.;  Wu W.-J.;  Lee S.M.-Y.;  Yan R.
Favorite  |  View/Download:2/0  |  Submit date:2018/11/06
The Presystemic Interplay between Gut Microbiota and Orally Administered Calycosin-7-O-b-D-Glucoside Journal article
DRUG METABOLISM AND DISPOSITION, 2015,Volume: 43,Issue: 10,Page: 1601-1611
Authors:  Jian-Qing Ruan;  Shang Li;  Ya-Ping Li;  Wen-Jin Wu;  Simon Ming-Yuen Lee;  Ru Yan
Favorite  |  View/Download:3/0  |  Submit date:2020/03/26
Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-D-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat Journal article
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2015,Volume: 1026,Page: 124
Authors:  Cai Y.;  Li S.;  Li T.;  Zhou R.;  Yan R.;  Wai A.T.-S.
Favorite  |  View/Download:17/0  |  Submit date:2018/10/30
Hepatic Glucuronidation  Intestinal Permeability  Isomerization  Microbial Metabolism  Scutellaria Radix  Systemic Exposure  
Research progress of the studies on the roots of Peucedanum praeruptorum dunn (Peucedani radix) Journal article
Pakistan Journal of Pharmaceutical Sciences, 2015,Volume: 28,Issue: 1,Page: 71
Authors:  Song Y.;  Jing W.;  Yan R.;  Wang Y.
Favorite  |  View/Download:8/0  |  Submit date:2018/10/31
Absolute Configuration  Angular-type Pyranocoumarins  Chemical Constituents  Peucedani Radix  Pharmacokinetics  Pharmacological Activities  
Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases Journal article
Chemico-Biological Interactions, 2014,Volume: 220,Page: 231-240
Authors:  Ruan J.-Q.;  Yan R.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/28
Calycosin  Glucuronidation  Metabolism  Regioselectivity  Udp-glucuronosyltransferases  
H-1 nuclear magnetic resonance based-metabolomic characterization of Peucedani Radix and simultaneous determination of praeruptorin A and praeruptorin B Journal article
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014,Volume: 93,Issue: SI,Page: 86-94
Authors:  Song, Yue-Lin;  Jing, Wang-Hui;  Chen, Yan-Gan;  Yuan, Yun-Fei;  Yan, Ru;  Wang, Yi-Tao
View  |  Adobe PDF(1142Kb)  |  Favorite  |  View/Download:284/20  |  Submit date:2018/11/01
Peucedani Radix  Metabolomic Profile  Quantitative H-1 Nmr  Praeruptorin a  Praeruptorin b  
Simultaneously enantiospecific determination of (+)-trans-khellactone, (+/-)-praeruptorin A, (+/-)-praeruptorin B, (+)-praeruptorin E, and their metabolites, (+/-)-cis-khellactone, in rat plasma using online solid phase extraction-chiral LC-MS/MS Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2014,Volume: 88,Page: 269
Authors:  Song Y.;  Jing W.;  Yang F.;  Shi Z.;  Yao M.;  Yan R.;  Wang Y.
Favorite  |  View/Download:11/0  |  Submit date:2018/10/31
Chiral Lc-ms/ms  Enantiospecific  Online Spe  Peucedani Radix  Pharmacokinetics  
Metabolic characterization of (±)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2014,Volume: 90,Page: 98
Authors:  Song Y.-L.;  Jing W.-H.;  Yan R.;  Wang Y.-T.
Favorite  |  View/Download:13/0  |  Submit date:2018/10/31
(±)-Praeruptorin A  In vivo  LightSight™ software  Metabolism  Peucedani Radix