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Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite  |  View/Download:8/0  |  Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation Journal article
MOLECULES, 2018,Volume: 23,Issue: 7
Authors:  Li, Zhi-Peng;  Liu, Hong-Bing;  Zhang, Quan-Wei;  Li, Li-Feng;  Bao, Wan-Rong;  Ma, Dik-Lung;  Leung, Chung-Hang;  Bian, Zhao-Xiang;  Lu, Ai-Ping;  Han, Quan-Bin
View  |  Adobe PDF(1815Kb)  |  Favorite  |  View/Download:361/11  |  Submit date:2018/10/30
Astragalus Polysaccharide  Quercetin  Cytokines  Macrophage  Foods  
Small Molecule Pin1 Inhibitor Blocking NF-B Signaling in Prostate Cancer Cells Journal article
CHEMISTRY-AN ASIAN JOURNAL, 2018,Volume: 13,Issue: 3,Page: 275-279
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Yang, Guanjun;  Wu, Chun;  Huang, Jie-Min;  Li, Guodong;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:26/0  |  Submit date:2018/10/30
Enzymes  Natural Products  Pin1  Protein-protein Interactions  Virtual Screening  
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:21/0  |  Submit date:2018/10/30
Drug Repurposing  Mitoxantrone  Nedd8  Ubiquitin  
Interaction of an Iridium(III) Complex with G-Quadruplex DNA and Its Application in Luminescent Switch-On Detection of Siglec-5 Journal article
Analytical Chemistry, 2016,Volume: 88,Issue: 20,Page: 10290-10295
Authors:  Lin S.;  Lu L.;  Kang T.-S.;  Mergny J.-L.;  Leung C.-H.;  Ma D.-L.
Favorite  |  View/Download:15/0  |  Submit date:2018/11/06
Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 8,Page: 4026
Authors:  Kang T.-S.;  Mao Z.;  Ng C.-T.;  Wang M.;  Wang W.;  Wang C.;  Lee S.M.-Y.;  Wang Y.;  Leung C.-H.;  Ma D.-L.
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening Journal article
MOLECULAR BIOSYSTEMS, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite  |  View/Download:4/0  |  Submit date:2020/07/30
Recent Advances in the Discovery and Development of Protein-Protein Interaction Modulators by Virtual Screening Book
2015
Authors:  Ma D.-L.;  Liu L.-J.;  Lin S.;  Wang M.;  Chan D.S.-H.;  Leung C.-H.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
Computer-aided drug discovery  Drug development  Molecular docking  Protein-protein interactions  Virtual screening  
Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe Journal article
Chemical Science, 2015,Volume: 6,Issue: 7,Page: 4284
Authors:  Lin S.;  Gao W.;  Tian Z.;  Yang C.;  Lu L.;  Mergny J.-L.;  Leung C.-H.;  Ma D.-L.
Favorite  |  View/Download:4/0  |  Submit date:2018/10/30
Group 9 organometallic compounds for therapeutic and bioanalytical applications Journal article
Accounts of Chemical Research, 2014,Volume: 47,Issue: 12,Page: 3614
Authors:  Ma D.-L.;  Chan D.S.-H.;  Leung C.-H.
Favorite  |  View/Download:3/0  |  Submit date:2018/10/30