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Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite  |  View/Download:5/0  |  Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
An Integrated Transfer Learning and Multitask Learning Approach for Pharmacokinetic Parameter Prediction Journal article
Molecular Pharmaceutics, 2019,Volume: 16,Issue: 2,Page: 533-541
Authors:  Ye Z.;  Yang Y.;  Li X.;  Cao D.;  Ouyang D.
Favorite  |  View/Download:16/0  |  Submit date:2019/02/14
Adme  Deep Learning  Multitask Learning  Pharmacokinetic Parameters  Transfer Learning  
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors Journal article
BIOTECHNOLOGY AND BIOENGINEERING, 2018,Volume: 115,Issue: 11,Page: 2828-2843
Authors:  Fu, Afu;  Peh, Yu Ming;  Ngan, Weida;  Wei, Na;  Luo, Kathy Qian
Favorite  |  View/Download:7/0  |  Submit date:2019/01/17
antimetastasis drug discovery  fluorescence resonance energy transfer  PI3K  AKT pathway  three dimensional tumor spheroids  zebrafish xenograft tumor model  
Internationalization of Traditional/Complementary Medicine products: market entry as medicine Journal article
CHINESE MEDICINE, 2018,Volume: 13
Authors:  Li, Jiatong;  Zhu, Jianfan;  Hu, Hao;  Harnett, Joanna E.;  Lei, Chi Ieong;  Chau, Ka Yin;  Chan, Ging;  Ung, Carolina Oi Lam
View  |  Adobe PDF(933Kb)  |  Favorite  |  View/Download:275/7  |  Submit date:2018/10/30
Traditional Chinese Medicines  Chinese Patent Medicines  Proprietary Chinese Medicines  Traditional And Complementary Medicine  Registration  Internationalization  Quality  Safety  Efficacy  
Surfactant-Free Interface Suspended Gold Graphitic Surface-Enhanced Raman Spectroscopy Substrate for Simultaneous Multiphase Analysis Journal article
ANALYTICAL CHEMISTRY, 2018,Volume: 90,Issue: 19,Page: 11183-11187
Authors:  Zhang, Liang;  Liu, Fang;  Zou, Yuxiu;  Hu, Xiaoxiao;  Huang, Siqi;  Xu, Yiting;  Zhang, Lufeng;  Dong, Qian;  Liu, Zhangkun;  Chen, Long;  Chen, Zhuo;  Tan, Weihong
Favorite  |  View/Download:19/0  |  Submit date:2018/10/30
Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future Conference paper
Authors:  Khan, Harron;  Jawad, Mohammad;  Kamal, Mohammad Amjad;  Baldi, Alessandra;  Xiao, Jianbo;  Nabavi, Seyed Mohammad;  Daglia, Maria
Favorite  |  View/Download:16/0  |  Submit date:2018/10/30
Antiplatelet  Preclinical studies  Structure-activity relationship (SAR) studies  Pharmacokinetic parameters  Safety profile  
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Cui, Guozhen;  Xin, Qiqi;  Tseng, Hisa Hui Ling;  Hoi, Maggie PuiMan;  Wang, Yan;  Yang, Binrui;  Choi, InLeng;  Wang, Yuqiang;  Yuan, Rong;  Chen, Keji;  Cong, Weihong;  Lee, Simon MingYuen
View  |  Adobe PDF(3018Kb)  |  Favorite  |  View/Download:281/11  |  Submit date:2018/10/30
Cardioprotection  Angiogenesis  ADTM  Zebrafish  VEGF  
Pharmacokinetics of Chinese medicines: strategies and perspectives Journal article
CHINESE MEDICINE, 2018,Volume: 13
Authors:  Yan, Ru;  Yang, Ying;  Chen, Yijia
Favorite  |  View/Download:19/0  |  Submit date:2018/10/30
Chinese Medicines  Pharmacokinetic Strategy  Pharmacokinetics-pharmacodynamics Relevance  Gut Microbiota  Global Pharmacokinetics-pharmacodynamics  
Computer-Aided Formulation Design for a Highly Soluble Lutein-Cyclodextrin Multiple-Component Delivery System Journal article
MOLECULAR PHARMACEUTICS, 2018,Volume: 15,Issue: 4,Page: 1664-1673
Authors:  Zhao, Qianqian;  Miriyala, Nikhila;  Su, Yan;  Chen, Weijie;  Gao, Xuejiao;  Shao, Ling;  Yan, Ru;  Li, Haifeng;  Yao, Xiaojun;  Cao, Dongsheng;  Wang, Yitao;  Ouyang, Defang
View  |  Adobe PDF(4697Kb)  |  Favorite  |  View/Download:550/42  |  Submit date:2018/10/30
Lutein  Cyclodextrin  Multiple-component System  Molecular Dynamics Simulation  Bioavailability  Computer-aided Formulation Design  
European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States Journal article
PHYTOMEDICINE, 2018,Volume: 42,Page: 219-225
Authors:  Qu, Liping;  Zou, Wenjun;  Wang, YiTao;  Wang, Mei
View  |  Adobe PDF(916Kb)  |  Favorite  |  View/Download:577/51  |  Submit date:2018/10/30
European Regulation Model  Hmp  Eu Monograph  Tur  Weu-ma