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Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish Journal article
Archives of Toxicology, 2019,Volume: 93,Issue: 1,Page: 189-206
Authors:  Liao Q.;  Li S.;  Siu S.W.I.;  Morlighem J.-E.R.L.;  Wong C.T.T.;  Wang X.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite  |  View/Download:17/0  |  Submit date:2019/04/04
Anti-epilepsy  Disulfide Bond  Neuroactive Peptides  Neuroprotection  Protein Docking  Voltage-gated Sodium Ion Channel Blocker  
N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF Journal article
MOLECULAR NEUROBIOLOGY, 2018,Volume: 55,Issue: 3,Page: 2258-2267
Authors:  Luo, Dan;  Zhao, Jia;  Cheng, Yuanyuan;  Lee, Simon Ming-Yuen;  Rong, Jianhui
Favorite  |  View/Download:10/0  |  Submit date:2018/10/31
Parkinson's disease  Neuroprotection  N-propargyl caffeamide (PACA)  NGF/TrkApathway  PI3K/Akt  ERK1/2  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View  |  Adobe PDF(2766Kb)  |  Favorite  |  View/Download:362/9  |  Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways Journal article
REDOX BIOLOGY, 2017,Volume: 11
Authors:  Zhang, Chao;  Li, Chuwen;  Chen, Shenghui;  Li, Zhiping;  Jia, Xuejing;  Wang, Kai;  Bao, Jiaolin;  Liang, Yeer;  Wang, Xiaotong;  Chen, Meiwan;  Li, Peng;  Su, Huanxing;  Wan, Jian-Bo;  Lee, Simon Ming Yuen;  Liu, Kechun;  He, Chengwei
Favorite  |  View/Download:24/0  |  Submit date:2018/10/30
Berberine  Hormesis  Neuroprotection  Pc12 Cells  Zebrafish  
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Zhang, Chao;  Li, Chuwen;  Chen, Shenghui;  Li, Zhiping;  Ma, Lijuan;  Jia, Xuejing;  Wang, Kai;  Bao, Jiaolin;  Liang, Yeer;  Chen, Meiwan;  Li, Peng;  Su, Huanxing;  Lee, Simon Ming Yuen;  Liu, Kechun;  Wan, Jian-Bo;  He, Chengwei
Favorite  |  View/Download:23/0  |  Submit date:2018/10/30
Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NEUROMOLECULAR MEDICINE, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Shengquan Hu;  Liang Wang;  Shinghung Mak;  Zaijun Zhang;  Daping Xu;  Haitao Li;  Yide Li;  Yuanjia Hu;  Simon Ming Yuen Lee;  Yuqiang Wang;  Yifan Han
Favorite  |  View/Download:239/0  |  Submit date:2020/01/16
Parkinson’s Disease  Mef2d  Neuroprotection  Mpp++++  Gsk3β  Danshensu/tetramethylpyrazine Derivative  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
American Journal of Chinese Medicine, 2016,Volume: 44,Issue: 7,Page: 1349-1361
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang;  Simon Ming-Yuen Lee
Favorite  |  View/Download:7/0  |  Submit date:2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease Journal article
Free Radical Biology and Medicine, 2015,Volume: 84,Page: 331
Authors:  Zaijun Zhang;  Guohui Li;  Samuel S.W. Szeto;  Cheong Meng Chong;  Quan Quan;  Chen Huang;  Wei Cui;  Baojian Guo;  Yuqiang Wang;  Yifan Han;  K.W. Michael Siu;  Simon Ming Yuen Lee;  Ivan K. Chu
Favorite  |  View/Download:8/0  |  Submit date:2018/10/30
Anti-inflammation  Freeradicals  Neuroprotection  Nrf2 Nf-κb  Parkinsondisease  Proteomics  
Cortex Fraxini (Qingpi) Protects Rat Pheochromocytoma Cells against 6-Hydroxydopamine-Induced Apoptosis Journal article
Parkinson's Disease, 2015,Volume: 2015
Authors:  Jing-Jie Li;  Shi-Ya Zhou;  Huan Zhang;  Kim-Hung Lam;  Simon Ming-Yuen Lee;  Peter Hoi-Fu Yu;  Shun-Wan Chan
Favorite  |  View/Download:5/0  |  Submit date:2018/11/06
A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-kappa B and the PKC alpha/PI3-K/Akt pathways Journal article
NEUROCHEMISTRY INTERNATIONAL, 2014,Volume: 78,Page: 76-85
Authors:  Xu, Da-Ping;  Zhang, Kun;  Zhang, Zai-Jun;  Sun, Ye-Wei;  Guo, Bao-Jian;  Wang, Yu-Qiang;  Hoi, Pui-Man;  Han, Yi-Fan;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:4/0  |  Submit date:2020/04/15
Neuroinflammation  Tetramethylpyrazine Derivative  6-hydroxydopamine  Neuroprotection