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Insulin-like growth factor-1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone-induced oxidative injury Journal article
BRITISH JOURNAL OF PHARMACOLOGY, 2018,Volume: 175,Issue: 1,Page: 125-139
Authors:  Liao, Rifang;  Yan, Fengxia;  Zeng, Zhuanping;  Wang, Haitao;  Qiu, Kaifeng;  Xu, Jinying;  Zheng, Wenhua
Favorite  |  View/Download:13/0  |  Submit date:2018/10/30
Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway Journal article
MOLECULAR NEUROBIOLOGY, 2017,Volume: 54,Issue: 9,Page: 6931-6943
Authors:  Liao, Rifang;  Yan, Fengxia;  Zeng, Zhuanping;  Farhan, Mohd;  Little, Peter;  Quirion, Remi;  Srivastava, Lalit K.;  Zheng, Wenhua
Favorite  |  View/Download:12/0  |  Submit date:2018/10/30
Amiodarone  Foxo3a  Akt  Antiarrhythmic  Apoptosis  Neuroprotection  
H2O2 attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor Journal article
ONCOTARGET, 2017,Volume: 8,Issue: 39,Page: 65313-65328
Authors:  Zeng, Zhiwen;  Wang, Dejun;  Gaur, Uma;  Liao Rifang;  Wang, Haitao;  Zheng, Wenhua
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
H2o2  Sh-sy5y  Nr2b  Nmda  Igf-1r  
Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway Journal article
CELLULAR SIGNALLING, 2012,Volume: 24,Issue: 1,Page: 17-24
Authors:  Wang, HT;  Zhang, QS;  Wen, Q;  Zheng, YX;  Philip, L;  Jiang, H;  Lin, J;  Zheng, WH
Favorite  |  View/Download:6/0  |  Submit date:2019/01/10
Pras40  Tumorigenesis  Insulin Resistance  Pi3k/akt  Mtorc1  
Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and Its survival signaling properties in rat hippocampal neurons Journal article
Journal of Biological Chemistry, 2009,Volume: 284,Issue: 2,Page: 855-861
Authors:  Zheng W.-H.;  Quirion R.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/21
Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival Journal article
Journal of Neurochemistry, 2004,Volume: 89,Issue: 4,Page: 844-852
Authors:  Zheng W.-H.;  Quirion R.
Favorite  |  View/Download:2/0  |  Submit date:2018/12/21
Akt  Bdnf  Hippocampal Neurons  Igf-1  Mapk  
Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons Journal article
Molecular Pharmacology, 2002,Volume: 62,Issue: 2,Page: 225-233
Authors:  Zheng W.-H.;  Kar S.;  Quirion R.
Favorite  |  View/Download:2/0  |  Submit date:2018/12/21
Insulin-like growth factor-1-induced phosphorylation of the Forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells Journal article
Journal of Biological Chemistry, 2000,Volume: 275,Issue: 50,Page: 39152-39158
Authors:  Zheng W.-H.;  Kar S.;  Quirion R.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/21
Stimulation of protein kinase C modulates insulin-like growth factor-1- induced Akt activation in PC12 cells Journal article
Journal of Biological Chemistry, 2000,Volume: 275,Issue: 18,Page: 13377-13385
Authors:  Zheng W.-H.;  Kar S.;  Quirion R.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/21