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Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library Journal article
Journal of Medicinal Chemistry, 2019,Volume: 62,Issue: 6,Page: 2928-2937
Authors:  Shaikh F.;  Zhao Y.;  Alvarez L.;  Iliopoulou M.;  Lohans C.;  Schofield C.J.;  Padilla-Parra S.;  Siu S.W.I.;  Fry E.E.;  Ren J.;  Stuart D.I.
Favorite  |  View/Download:1/0  |  Submit date:2019/04/04
2-O-β-D-glucopyranosyl-L-ascorbic acid, a novel vitamin C derivative fromLycium barbarum, prevents oxidative stress Journal article
Redox Biology, 2019,Volume: 24
Authors:  Shen-Fei Wang;  Xin Liu;  Mo-Yu Ding;  Shuangcheng Ma;  Jing Zhao;  Ying Wang;  Shaoping Li
Favorite  |  View/Download:3/0  |  Submit date:2019/11/22
Ascorbic Acid  2-o-β-d-glucopyranosyl-l-ascorbic Acid (Aa-2βg)  Oxidative Stress  Lycium Barbarum  Nuclear Factor E2-related Factor 2 (Nrf2)  
Investigation of the impact of ferrous species on the performance of common oilfield scale inhibitors for mineral scale control Journal article
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING, 2019,Volume: 172,Page: 288-296
Authors:  Zhang, Ping;  Zhang, Zhang;  Liu, Yuan;  Kan, Amy T.;  Tomson, Mason B.
Favorite  |  View/Download:0/0  |  Submit date:2019/01/17
Scale inhibitor  Barium sulfate  Ferrous  Anoxic  Inhibition efficiency  
Pharmacological Inhibition of LSD1 for Cancer Treatment Journal article
MOLECULES, 2018,Volume: 23,Issue: 12
Authors:  Yang, Guan-Jun;  Lei, Pui-Man;  Wong, Suk-Yu;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:3/0  |  Submit date:2019/01/17
LSD1  demethylase  histone  breast cancer  prostate cancer  acute myeloid leukemia  cancer therapy  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:12/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors Journal article
BIOTECHNOLOGY AND BIOENGINEERING, 2018,Volume: 115,Issue: 11,Page: 2828-2843
Authors:  Fu, Afu;  Peh, Yu Ming;  Ngan, Weida;  Wei, Na;  Luo, Kathy Qian
Favorite  |  View/Download:1/0  |  Submit date:2019/01/17
antimetastasis drug discovery  fluorescence resonance energy transfer  PI3K  AKT pathway  three dimensional tumor spheroids  zebrafish xenograft tumor model  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View  |  Adobe PDF(2009Kb)  |  Favorite  |  View/Download:309/46  |  Submit date:2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation