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Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors Journal article
BIOTECHNOLOGY AND BIOENGINEERING, 2018,Volume: 115,Issue: 11,Page: 2828-2843
作者:  Fu, Afu;  Peh, Yu Ming;  Ngan, Weida;  Wei, Na;  Luo, Kathy Qian
收藏  |  浏览/下载:3/0  |  提交时间:2019/01/17
antimetastasis drug discovery  fluorescence resonance energy transfer  PI3K  AKT pathway  three dimensional tumor spheroids  zebrafish xenograft tumor model  
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy Journal article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018,Volume: 57,Issue: 40,Page: 13091-13095
作者:  Yang, Guan-Jun;  Wang, Wanhe;  Mok, Simon Wing Fai;  Wu, Chun;  Law, Betty Yuen Kwan;  Miao, Xiang-Min;  Wu, Ke-Jia;  Zhong, Hai-Jing;  Wong, Chun-Yuen;  Wong, Vincent Kam Wai;  Ma, Dik-Lung;  Leung, Chung-Hang
收藏  |  浏览/下载:28/0  |  提交时间:2018/10/30
Drug Discovery  Epigenetics  Medicinal Chemistry  Triple-negative Breast Cancer  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
作者:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
浏览  |  Adobe PDF(2009Kb)  |  收藏  |  浏览/下载:347/49  |  提交时间:2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
作者:  Ma, Xuewei;  Hu, Yichen;  Li, Xin;  Zheng, Xiaoting;  Wang, Yitao;  Zhang, Jinming;  Fu, Chaomei;  Geng, Funeng
浏览  |  Adobe PDF(4337Kb)  |  收藏  |  浏览/下载:286/12  |  提交时间:2018/10/30
Ulcerative Colitis  Periplaneta Americana  16s Rrna  Gut Microbiota  Intestinal Immunity  
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
作者:  Cui, Guozhen;  Xin, Qiqi;  Tseng, Hisa Hui Ling;  Hoi, Maggie PuiMan;  Wang, Yan;  Yang, Binrui;  Choi, InLeng;  Wang, Yuqiang;  Yuan, Rong;  Chen, Keji;  Cong, Weihong;  Lee, Simon MingYuen
浏览  |  Adobe PDF(3018Kb)  |  收藏  |  浏览/下载:123/3  |  提交时间:2018/10/30
Cardioprotection  Angiogenesis  ADTM  Zebrafish  VEGF  
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 830,Page: 17-25
作者:  Zhang, Le-Le;  Feng, Zhe-Ling;  Su, Min-Xia;  Jiang, Xiao-Ming;  Chen, Xiuping;  Wang, Yitao;  Li, Ao;  Lin, Li-Gen;  Lu, Jin-Jian
浏览  |  Adobe PDF(3226Kb)  |  收藏  |  浏览/下载:175/23  |  提交时间:2018/10/30
Nagilactone e  Non-small Cell Lung Cancer  Cyclin B1  Cell Cycle  Apoptosis  
ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database Journal article
JOURNAL OF CHEMINFORMATICS, 2018,Volume: 10
作者:  Dong, Jie;  Wang, Ning-Ning;  Yao, Zhi-Jiang;  Zhang, Lin;  Cheng, Yan;  Ouyang, Defang;  Lu, Ai-Ping;  Cao, Dong-Sheng
收藏  |  浏览/下载:17/0  |  提交时间:2018/10/30
ADMETlab  ADMET  Drug-likeness  ADMET database  Drug discovery  Cheminformatics  
UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
作者:  Xia, Fangbo;  Li, Ao;  Chai, Yushuang;  Xiao, Xiao;  Wan, Jianbo;  Li, Peng;  Wang, Yitao
浏览  |  Adobe PDF(3535Kb)  |  收藏  |  浏览/下载:167/17  |  提交时间:2018/10/30
An-gong-niu-huang Wan  Cinnabar  Realgar  Metabonomics  Detoxification  Inflammation  
Fast identification of anticancer constituents in Forsythiae Fructus based on metabolomics approaches Journal article
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018,Volume: 154,Page: 312-320
作者:  Bao, Jiaolin;  Ding, Ren-Bo;  Jia, Xuejing;  Liang, Yeer;  Liu, Fang;  Wang, Kai;  Zhang, Chao;  Li, Peng;  Wang, Yitao;  Wan, Jian-Bo;  He, Chengwei
浏览  |  Adobe PDF(2154Kb)  |  收藏  |  浏览/下载:195/22  |  提交时间:2018/10/30
Forsythiae Fructus  Anticancer  Metabolomics  Multivariate Data Analysis  B16-f10 Melanoma  
Computer-Aided Formulation Design for a Highly Soluble Lutein-Cyclodextrin Multiple-Component Delivery System Journal article
MOLECULAR PHARMACEUTICS, 2018,Volume: 15,Issue: 4,Page: 1664-1673
作者:  Zhao, Qianqian;  Miriyala, Nikhila;  Su, Yan;  Chen, Weijie;  Gao, Xuejiao;  Shao, Ling;  Yan, Ru;  Li, Haifeng;  Yao, Xiaojun;  Cao, Dongsheng;  Wang, Yitao;  Ouyang, Defang
浏览  |  Adobe PDF(4697Kb)  |  收藏  |  浏览/下载:228/28  |  提交时间:2018/10/30
Lutein  Cyclodextrin  Multiple-component System  Molecular Dynamics Simulation  Bioavailability  Computer-aided Formulation Design